Thanks to everyone that responded to my question.   It has encouraged a nice 
discussion and I have learned from it.


 
Martha Ward, MT (ASCP) QIHC
Manager

Molecular Diagnostics Lab
Medical Center Boulevard  \  Winston-Salem, NC 27157
p 336.716.2109  \  f 336.716.5890  
mw...@wakehealth.edu  
 
 



-----Original Message-----
From: histonet-boun...@lists.utsouthwestern.edu 
[mailto:histonet-boun...@lists.utsouthwestern.edu] On Behalf Of Bob Richmond
Sent: Thursday, September 12, 2013 1:56 PM
To: Histonet@lists.utsouthwestern.edu
Subject: [Histonet] Re: Minimum sample size for breast markers

Pathologists need to be very ready to note that a breast cancer sample size is 
small, and that the markers need to be repeated on the lumpectomy or mastectomy 
specimen.

This is easier said than done. Popping a Dolly-size breast into too-small 
container and dribbling a little formalin on it is not going to preserve the 
specimen adequately. Even with a moderate-sized lumpectomy specimen the 
formaldehyde penetration is going to be chancy.

This is an issue that surgeons, OR nurses, and too many pathologists are unable 
to understand. The pathologist has to arrange to receive the specimen promptly 
and get the tumor cut into formalin. Easier said than done.

The woman's cancer care depends on this getting done. It's non-trivial. And 
colon cancer is distinctly the next frontier for this problem.

Bob Richmond
Samurai Pathologist
Maryville TN
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