I've been having the same issue since building a new system a couple months ago. The frequency is inconsistent, but rarely happens more than once per day. Sometimes I'll lose my keyboard mid-sentence, and other times I won't be able to unlock the system in the morning.
Oddly, my USB mouse (a Razer Naga) always still works, and the side buttons which act as a number pad also always work. However, by USB hub loses power, and neither it nor my keyboard ever regain power or functionality when re-plugging or switching ports. It's always fixed by a reboot. I'm on a Threadripper 3990x with an ASUS ROG Zenith II Extreme motherboard. Here's the snippet from /var/log/syslog: Jan 14 19:37:19 amaranth systemd[1]: fprintd.service: Succeeded. Jan 14 19:38:44 amaranth kernel: [37857.592954] xhci_hcd 0000:49:00.3: Mismatch between completed Set TR Deq Ptr command & xHCI internal state. Jan 14 19:38:44 amaranth kernel: [37857.592957] xhci_hcd 0000:49:00.3: ep deq seg = 000000003ccd0405, deq ptr = 000000006daebfd1 Jan 14 19:38:45 amaranth kernel: [37858.593779] xhci_hcd 0000:49:00.3: AMD-Vi: Event logged [IO_PAGE_FAULT domain=0x0035 address=0x0 flags=0x0000] Jan 14 19:38:50 amaranth kernel: [37863.667171] xhci_hcd 0000:49:00.3: xHCI host not responding to stop endpoint command. Jan 14 19:38:50 amaranth kernel: [37863.667178] xhci_hcd 0000:49:00.3: xHCI host controller not responding, assume dead Jan 14 19:38:50 amaranth kernel: [37863.667220] xhci_hcd 0000:49:00.3: HC died; cleaning up Jan 14 19:38:50 amaranth kernel: [37863.667255] usb 9-3: USB disconnect, device number 2 Jan 14 19:38:50 amaranth kernel: [37863.667258] usb 9-3.1: USB disconnect, device number 4 Jan 14 19:38:50 amaranth kernel: [37863.667447] usb 10-3: USB disconnect, device number 2 Jan 14 19:38:50 amaranth kernel: [37863.667449] usb 10-3.2: USB disconnect, device number 4 Jan 14 19:38:50 amaranth kernel: [37863.667451] usb 10-3.2.4: USB disconnect, device number 5 Jan 14 19:38:50 amaranth kernel: [37863.668402] usb 10-4: USB disconnect, device number 3 Jan 14 19:38:50 amaranth kernel: [37863.735579] usb 9-3.2: USB disconnect, device number 6 Jan 14 19:38:50 amaranth kernel: [37863.735581] usb 9-3.2.3: USB disconnect, device number 7 Jan 14 19:38:50 amaranth acpid: input device has been disconnected, fd 17 Jan 14 19:38:50 amaranth acpid: input device has been disconnected, fd 8 Jan 14 19:38:50 amaranth acpid: input device has been disconnected, fd 9 Jan 14 19:38:50 amaranth kernel: [37863.979627] usb 9-3.2.4: USB disconnect, device number 9 Jan 14 19:38:50 amaranth kernel: [37863.979630] usb 9-3.2.4.4: USB disconnect, device number 10 Jan 14 19:38:50 amaranth kernel: [37864.076604] usb 9-4: USB disconnect, device number 3 Jan 14 19:38:50 amaranth kernel: [37864.076833] usb 9-5: USB disconnect, device number 5 Jan 14 19:38:50 amaranth acpid: input device has been disconnected, fd 7 Jan 14 19:38:50 amaranth acpid: input device has been disconnected, fd 10 Jan 14 19:38:50 amaranth kernel: [37864.231560] usb 9-6: USB disconnect, device number 8 Jan 14 19:38:50 amaranth acpid: input device has been disconnected, fd 11 Jan 14 19:38:50 amaranth acpid: input device has been disconnected, fd 12 -- You received this bug notification because you are a member of Kernel Packages, which is subscribed to linux in Ubuntu. https://bugs.launchpad.net/bugs/1908894 Title: USB controllers disconnects after random time Status in linux package in Ubuntu: Confirmed Bug description: Since I installed Ubuntu on my new convertible laptop, I got issues with the USB. Just after boot my USB controller is working properly (I can connect usb sticks, mices, and my internal camera works) and at some point long after it suddenly stop working (mices suddenly stop moving even when used, webcam and sticks no more detected). This can happend few minuts after boot, or several days after. Yet I have not been able to find what triggers the failure. It happends at any time during normal usage of the computer, including during the usb usage. more concrete infos: after failure, I get $ dmesg [ 2671.894099] perf: interrupt took too long (2512 > 2500), lowering kernel.perf_event_max_sample_rate to 79500 [ 3262.197917] xhci_hcd 0000:03:00.3: Mismatch between completed Set TR Deq Ptr command & xHCI internal state. [ 3262.197927] xhci_hcd 0000:03:00.3: ep deq seg = 000000008dafef36, deq ptr = 000000005f96ce32 [ 3262.198052] xhci_hcd 0000:03:00.3: AMD-Vi: Event logged [IO_PAGE_FAULT domain=0x000a address=0x0 flags=0x0000] [ 3267.250397] xhci_hcd 0000:03:00.3: xHCI host not responding to stop endpoint command. [ 3267.250428] xhci_hcd 0000:03:00.3: xHCI host controller not responding, assume dead [ 3267.250463] xhci_hcd 0000:03:00.3: HC died; cleaning up [ 3267.250499] usb 1-3: USB disconnect, device number 2 [ 3267.311251] usb 1-4: USB disconnect, device number 3 and lsusb doesn't show my devices anymore, even the newly inserted ones config: Asus Zenbook flip 14 UM462DA ProblemType: Bug DistroRelease: Ubuntu 20.04 Package: linux-image-5.4.0-58-generic 5.4.0-58.64 ProcVersionSignature: Ubuntu 5.4.0-58.64-generic 5.4.73 Uname: Linux 5.4.0-58-generic x86_64 ApportVersion: 2.20.11-0ubuntu27.14 Architecture: amd64 AudioDevicesInUse: USER PID ACCESS COMMAND /dev/snd/controlC1: jimy 1523 F.... pulseaudio /dev/snd/controlC0: jimy 1523 F.... pulseaudio /dev/snd/pcmC1D0p: jimy 1523 F...m pulseaudio /dev/snd/timer: jimy 1523 f.... pulseaudio CasperMD5CheckResult: skip CurrentDesktop: KDE Date: Mon Dec 21 11:51:08 2020 InstallationDate: Installed on 2020-07-28 (146 days ago) InstallationMedia: Ubuntu 20.04 LTS "Focal Fossa" - Release amd64 (20200423) Lsusb: Bus 004 Device 001: ID 1d6b:0003 Linux Foundation 3.0 root hub Bus 003 Device 002: ID 8087:0a2b Intel Corp. Bus 003 Device 001: ID 1d6b:0002 Linux Foundation 2.0 root hub Bus 002 Device 001: ID 1d6b:0003 Linux Foundation 3.0 root hub Bus 001 Device 001: ID 1d6b:0002 Linux Foundation 2.0 root hub MachineType: ASUSTeK COMPUTER INC. ZenBook UX462DA ProcFB: 0 amdgpudrmfb ProcKernelCmdLine: BOOT_IMAGE=/boot/vmlinuz-5.4.0-58-generic root=UUID=ba0f4ac4-b614-4882-83d6-485690f9a61a ro quiet splash vt.handoff=7 RelatedPackageVersions: linux-restricted-modules-5.4.0-58-generic N/A linux-backports-modules-5.4.0-58-generic N/A linux-firmware 1.187.6 SourcePackage: linux UpgradeStatus: No upgrade log present (probably fresh install) dmi.bios.date: 09/28/2020 dmi.bios.vendor: American Megatrends Inc. dmi.bios.version: UX462DA.307 dmi.board.asset.tag: ATN12345678901234567 dmi.board.name: UX462DA dmi.board.vendor: ASUSTeK COMPUTER INC. dmi.board.version: 1.0 dmi.chassis.asset.tag: No Asset Tag dmi.chassis.type: 31 dmi.chassis.vendor: ASUSTeK COMPUTER INC. dmi.chassis.version: 1.0 dmi.modalias: dmi:bvnAmericanMegatrendsInc.:bvrUX462DA.307:bd09/28/2020:svnASUSTeKCOMPUTERINC.:pnZenBookUX462DA:pvr1.0:rvnASUSTeKCOMPUTERINC.:rnUX462DA:rvr1.0:cvnASUSTeKCOMPUTERINC.:ct31:cvr1.0: dmi.product.family: ZenBook Flip dmi.product.name: ZenBook UX462DA dmi.product.version: 1.0 dmi.sys.vendor: ASUSTeK COMPUTER INC. 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