Re: [Mauve-users] alignment of 15 genomes with varying degrees of similarity

2014-11-12 Thread Aaron Darling
The default parameters appear to work reasonably well over a range of divergences although at higher levels of nucleotide divergence, e.g. <65% identity, the aligner begins to lose sensitivity. When this happens some positionally homologous sites fail to become aligned. This issue is characterized

Re: [Mauve-users] alignment of 15 genomes with varying degrees of similarity

2014-11-12 Thread Anja Friedrich
Dear Aaron, I did not imply a bug, maybe there is something with the settings I used to create the SuperGenome. I was just wondering if the default settings for the progressiveMauve algorithm were acceptable if I have varying degrees of similarity between the genomes? Kind regards, Anja -