Best Configuratuion ( my.cnf ) for a DB with many users and large columns ( Images in BLOB Columns ) on a Website

Hey, what do you think is the best configuration ( my.cnf ) for running a database, which many users access at the same time ( Website - Portal ). We´ve also saved our Pictures ( nearly 3.500 rows ) in our database. Every coloumn is round about 60-70 Kbyte, so i had to use mediumblob columns.

Best Configuratuion ( my.cnf ) for a DB with many users and large columns ( Images in BLOB Columns ) on a Website]

Hey, what do you think is the best configuration ( my.cnf ) for running a database, which many users access at the same time ( Website - Portal ). We´ve also saved our Pictures ( nearly 3.500 rows ) in our database. Every coloumn is round about 60-70 Kbyte, so i had to use mediumblob columns.