Dear NMusers,
A single-dose of drug was given to healthy volunteers and a PK model
incorporating Michaelis-Menten distribution nicely captured the
concentration-time profile.
The same drug was given to healthy volunteers once daily for consecutive
7 days. The same PK model developed on the s
Alison,
Thanks for this, (the answer to my question from 2 years ago). This
will help greatly with some automated diagnostics/corrections in work
on automated model selection, especially with my favorite error message
MINIMIZATION TERMINATED DUE TO PROXIMITY OF NEXT ITERATION EST. TO A
VALUE A
This is another recent thread that I would like to comment on.
On the issue of LOCB vs LOCF: The question is discussed at great length
in NONMEM Users Guide VI, PREDPP, in chapter III, section B.2 Time-
Varying Concomitant Variables. The idea is that, prior to advancing the
state vector from time
My comments are attached.
On Sun, 27 May 2007 18:53:21 +0200, "Benjamin Ribba"
<[EMAIL PROTECTED]> said:
> Dear NMusers,
>
> 1. I have some difficulties to find information on the ODE solver
> implemented in NONMEM.
> Can anyone tell me about the numerical integrator(s) implemented when
> using
Hi Juergen
The LSODA solver is also implemented in the odesolve package in R and used
together with nlme for mixed-effects modeling in nlmeODE.
I don't think you will find many PKPD programs with more well-tuned ODE solvers
for mixed-effects modeling compared to NONMEM. You might also want t
