Dear Huali,
I am cutting out the unhappy portion of our discussion of this week-end,
and come back to your fundamental question as I understand it: You have
patients of different disease states and you suspect that the patients are
divided into groups (with different Vm point estimates but also
Time is running out to register for the eleventh Advanced Level Workshop on
Pharmacokinetic - Pharmacodynamic Data Analysis: A hands-on course using
WinNonlin to be held at Madingley Hall, Cambridge, UK from 17 to 21 May 2009,
presented by the Royal Pharmaceutical Society of Great Britain and t
I am looking for a solution to get around the limit of 20 input variables
in nonmem.
The message you get with more than 20 variables in $INPUT is this:
16 $INPUT: NO. OF DATA ITEMS EXCEEDS 20.
STOP 4 statement executed
I did not find anything in the archives or on the Web. I recall having
s
If you are not looking for workarounds, you'll need to wait for Nonmem
VII to be released.
Regards,
Katya
-
Ekaterina Gibiansky
Senior Director, PKPD, Modeling & Simulation
ICON Development Solutions
ekaterina.gibian...@iconplc.com
F
Andreas,You are correct that there isn't an easy way to change the limit of 20 data itemsBut, I know of 2 possible solutions:1. The official way. There is a way to do continuation lines in nonmem data sets, documentation below. But I have found this pretty cumbersome.2. The hack. When I've nee
Look in your NONMEM html\cont.htm.
The CONT data item lets you specify additional input records which can
be continued to allow more than 20 data items.
Here is a description in more detail.
http://www.cognigencorp.com/nonmem/nm/99aug272005.html
I found this by searching with Google for "NONME
Dear Andreas,
Isn't the limit you're referring to the maximum amount of etas/thetas, these
can be adjusted (see: http://www.icondevsolutions.com/nonmem_tip20.htm )
As far as I known the amount of data items can not be adjusted. If some of them
are not in use, you can use the DROP data item. The
Dear Andreas,
Before NM VII, PsN is a solution.
[create_cont_data.bat] is used to generate cont data set.
[execute -wrap_data modelfile] will run automatically.
But it depends on the structures of model and data set. If it doesn't work,
maybe we should add cont item manually.
B
Hi All,
PsN does this automatically when using the '-wrap_data' option of the
'execute' command. See
http://psn.sourceforge.net/PDF_docs/common_options_defaults_versions_psn.pdf
for more details.
Best regards,
Andy
Andrew Hooker, Ph.D.
Associate Professor of Pharmacometrics
Div. of Pharmacokine
Andreas,
PsN has functionality for automatically applying the CONT-data-item
approach mentioned by Mark and Nick.
To run your model in nonmem with more than 20 input variables, you would
simply type:
execute --wrap_data run1.mod
In a subdirectory PsN will create a new dataset and model file with
Andreas,
Some months ago I spent a few hours investigating this same problem. Below are
my notes. Currently I use the last approach (which is actually a workaround,
sorry...), that will hopefully be redundant when NM7 arrives,
best regards,
Ron
approaches for using more covariates in dataset:
Hi Ron,
Thanks for your summary.
In my case, it always shows an error that DV is positive and MDV is 1.
Maybe this indicates that in NMVI a new rule to check DV and MDV have been
added. The problem could be solved when CONT is 1 and MDV is 1, DV is set to
'.'.
Best regards,
Guangli
-O
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