Dear all,
thanks to Mats suggestion, using full cov matrix did assign Eta more
reasonably to Ka, with not very precised estimates
another suggestion is that, there may be some underline difference in the
structure model between sparse MD data, and rich SD -- by visual inspection of
sparse
Dear all,
I agree that this kind of behaviour suggests there is some problem with
the model (most likely a lack of exchangeability). I think the ideas
suggested are all good, but the first thing I would try is to separate
residual noise for the two studies with an indicator variable. It is
like
Please unsubscribe me from the NONMEM User group.Thank you! Marieke
Please unsubscribe me from the NONMEM User group.Thank you! Yanhong
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