Nick,
Thanks for your comments. We (+ Andreas Steingötter + Rickmer Braren) are
more rooted in physiology, physics, and statistics, so critical response
from the PK marked is highly appreciated.
You wrote:
On the other hand if the goal is to estimate the size of one or more
critical
Andreas,
I doubt that one can give a general answer (without looking on the
specific model) but here is my understanding of the situation:
In over-parametrized models, there is one or more degenerate directions
(in the parameter space) where changes of the parameters do not change
the fit
