We noticed that gfortran installed on Windows 7 and Linux workstations are
32-bit and 64-bit, respectively. Are there ways to install 64-bit gfortran
on Windows 7?
Regards,
Santosh
On Thu, Mar 10, 2011 at 9:42 AM, Santosh wrote:
> I forgot to mention..
>
> Fortran compiler: gfortran 4.5.0
> Th
Jean, I don't have previous PK/PD data, only PK. Joseph, thanks for your interesting suggestion. Unfortunatly, I will be out of the office for a week, so I can't check it right now. I'll get back with the results. Regards, Andreas.
Dear Andreas,
Perhaps one strategy would be to use the data from the previous PK/PD study and
to first fit the PK data. Then fit your nice Emax model based on the PK model
. You could fit simultaneously the PK/PD from the previous study. From this
point you have several path you can take to
Joseph,
with adding IIV on dose I meant multiplying DOSE in the Emax model with a
bioavailability parameter F with its theta fixed to 1 and omega fixed to
55% CV:
E.g.:
IPRED = BL + EMAX * F*DOSE/(ED50+F*DOSE)
where F = theta(F)*exp(eta(F))
Sorry for not being clear. Regards, Andreas.
Andr
Dear Andreas,
When you say you add IIV on dose, I'm not sure exactly what you mean but
suggest you need to take a 2 step approach. In order to replicate variability
in dose, you will need to simulate doses with variability, and then in a second
step use these simulated doses to estimate the Em
Dear group,
I am currently analyzing some dose-response data for one of our drugs. A
simple Emax model nicely described the dose-response relationship for the
principal PD variable (a continuous measure). Unfortunately, no PK data
was obtained from the subjects in the PD study. Since the variab
