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Thank you,
Rob
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Eleveld, DJ
Sent: Tuesday, May 31, 2011 2:48 PM
To: ???; nmusers@globomaxnm.com
Subject: RE: [NMusers] question about shinkage
Hi Li,
Well, do you h
Hi Li,
Well, do you have rich data and a small number of subjects?
How much shrinkage exactly? A very small negative number might just be due to
(hopefully) non-important numerical issues. It could also be due to early
termination of the estimation, not doing enough iterations, problems with
Hi Li
I’m not aware of specific interpretations for negative shrinkage other than the
evaluation of the SD of the ETAs is greater than the estimate of the sqrt of
OMEGA for the same parameter. Since OMEGA itself is an estimate then ETA
shrinkage may occur due to either the EBEs being underdisp
Dear all,
In that respect, let me add my 10 cents for installing MPI on a 64 bit
windows 7 platform:
Download a 64 bit version of MPI, e.g.:
http://www.mcs.anl.gov/research/projects/mpich2/downloads/tarballs/1.3.2/mpi
ch2-1.3.2-win-x86-64.msi or later and run (the ICON supplied version is 32
bit)
The Mac OS X version of the companion graphical interface to NONMEM
7.2.0, PDx-Pop 5.0, is now available for download from the ICON ftp
site:
ftp://ftp.globomaxnm.com/Public/pdxpop/PDx-Pop5.0/Mac-OSX/
The installer file is PDXinstall50Mac.zip.
PDx-Pop 5.0 features full compatibility
Hi,
I have two questions about warning 68:
(WARNING 68) THE INTEGER FUNCTION IS BEING USED OUTSIDE OF A SIMULATION
BLOCK. IF THE INTEGER VALUE AFFECTS THE VALUE OF THE OBJECTIVE FUNCTION,
THEN AN ERROR WILL PROBABLY OCCUR.
First question: In what kind of cases the Integer value will affect the
All:
I appreciate your efforts in working out the MPI installations for
various platforms, and disseminating the information to NONMEM users. I
will keep track of this information and add to the documentation to make
things clearer.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Dev
How to build a PhysioPD™ model
by
Rebecca Baillie, PhD
Rosa & Co
June 20, 2011
12:00 - 1:00 pm EDT
You are invited to attend Dr. Baillie's webinar How to build a PhysioPD model
on June 20, 2011 at 12:00 pm EDT (GMT -5:00). Dr. Baillie's talk will explore
the development of a PhysioPD model
Hi dear all,
I have a question about shinkage. I read an article about shinkage (Radojka
M. Savic and Mats O. Karlsson Importance of Shrinkage in Empirical Bayes
Estimates for Diagnostics: Problems and Solutions 2009) and try to use
shinkage to diagnose my model. An ETA-shinkage is negative in my
Hi Paul,
Well, I think it's an obvious solution to compile a 64bit mpich, when
running on a 64bit OS and the precompiled libmpich archive delivered by
NONMEM is a 32bit one.
Cheers!
Hannes Kopitz
External Consultant
CI Pharmaceuticals - Service Delivery
D41/221
HPC: D041/001
Phone: +49(0)6151 7
Hi!
On 5/31/2011 8:27 AM, hannes.kop...@merck.de wrote:
The issue with the libmpich.a was the same for me on a 64bit linux with the
gfortran 4.5 and mpd.
Did you resolve the issue in a similar way (overwriting libmpich.a), or
did you come up with a more elegant solution?
But I don't see th
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