RE: [NMusers] Different EBE estimation between original and enriched dataset with MDV=1

Pascal: There is one more consideration. If your model depends on the use of covariate data, then during the numerical integration from time t1 to t2, where t1 and t2 are times of two contiguous records, which have values of the covariate c1 and c2, respectively, NONMEM uses the covariate at ti

RE: [NMusers] Different EBE estimation between original and enriched dataset with MDV=1

My receipt of Bill Denney's e-mail lagged somewhat. My explanation is similar to his. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics, R&D ICON Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.co