Re: [NMusers] Different EBE estimation between original and enriched dataset with MDV=1

Hi Leonid, Thanks for the additional suggestion to use ADVAN13. I was able to increase TOL up to 16, SIGL to 14, but still have the same biases for the moderate to almost flat initial slope after baseline when using dummy points spaced every 1 unit of time. When I reduce number of dummy points

Re: [NMusers] Different EBE estimation between original and enriched dataset with MDV=1

Hi Pascal, This looks like a bug (in Nonmem or in your code) to me. With TOL=16, there should be no numerical problems with ODE. Could you provide more details (code with the initial conditions + sample of the data for one subject where you have this problem)? Thanks Leonid