[NMusers] NONMEM 7.3.0 is now available

2013-12-05 Thread Bauer, Robert
Dear NMUSERS: NONMEM 7.3.0 is now available. Please visit the site ftp://nonmem.iconplc.com/Public/nonmem730 and view readme_730.pdf. This file lists new features of NONMEM 7.3.0 and bug fixes. The guide nm730.pdf contains a more detailed description of the new features. Lisa Wilhelm has been

RE: [NMusers] Getting rid of correlation issues between CL and volume parameters

2013-12-05 Thread Pavel Belo
Hello Nele,   You can try Ke, V2, K23 and K32 instead of Cl, Q, V2 and V3. It  may mostly remove the correlation between V2 and Cl because  Cl=V2*Ke. If F1 is not a parameter in your model and you give  SC doses, it is the same. You have (Cl/F1) = (V2/F1)*Ke, i.e.  your parameters are "app