Thank you, Leonid, for your answer but you can see (below) it’s not a
rounding issue ; there are udge variations of time ?!!!
*INPUT FILE :*
ID DATE TIME DV AMT
RATE MDV EVID
3 1 00
2000
Dear Diane-Charlotte,
NONMEM interprets DATE in your in-data and makes use of it. If you don’t want
that, rename DATE to something that is not recognized. Each date aboce the
first adds 24 h to your time column
Best regards,
Mats
Mats Karlsson, PhD
Professor of Pharmacometrics
Dept of Pharmace
If you subtract (DATE-1) * 24 from TIME in the output file it will match TIME
in input file.
NONMEM reads DATE as a DATE data item, that’s why. I suspect you won’t have
this if you choose another column name for DATE (e.g. DAY). Note that this may
also have an effect on the estimation process an
I think the problem is the DATE column. If this column is called DATE also in
$INPUT it will be interpreted as a date and NONMEM will adjust your time
according to that date, adding 24 hours.
Even though you put =DROP on this column NM will recognise DATE. Call is
something else unless you want
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