Re: [NMusers] RE: Link different thetas to same omega using mu referencing

Hi Jacob, Yes, THETA(4) would represent the typical value (before exponentiation). In summary, writing your covariate code after the definition of MU should circumvent the time-varying problem. If you want everything on a log scale you could try:OCL=MU_1+ETA(1)CL=EXP(OCL+CLCOV) The issue with tr

Re: [NMusers] RE: Link different thetas to same omega using mu referencing

I think the following code should work: IF(CAT.EQ.1) CLCOV = THETA(1)IF(CAT.EQ.2) CLCOV = THETA(2)IF(CAT.EQ.3) CLCOV = THETA(3)MU_1 = THETA(4) CL = EXP(MU_1+ETA(1))*(1+CLCOV) $OMEGA BLOCK(1) 0.1 Mannie From: Rupert Austin To: "'Sadler, Brian'" ; nmusers@globomaxnm.com Sent: Wednesday,

RE: [NMusers] RE: Link different thetas to same omega using mu referencing

Rupert, I believe at least in principle you are right (I am not sure of the specifics for NONMEM but I am generally familiar with the implementation challenges that time varying covariates pose for EM methods. ) The basic problem is that mu-modeling works to speed up EM methods because the EM u

RE: [NMusers] RE: Link different thetas to same omega using mu referencing

I’m not sure that Brian’s suggestion is acceptable due to the following constraint I quote from one of the NONMEM manuals: “Time dependent covariates cannot be part of the MU_ equation” If CAT is time-varying (as suggested by Jacob) then “MU_1 = CAT1*THETA(1) + CAT2*THETA(2) + CAT3*THETA(

[NMusers] RE: Link different thetas to same omega using mu referencing

Hi Jacob, I suggest: CAT1=0 CAT2=0 CAT3=0 IF(CAT.EQ.1) CAT1=1 IF(CAT.EQ.2) CAT2=1 IF(CAT.EQ.3) CAT3=1 MU_1 = CAT1*THETA(1) + CAT2*THETA(2) + CAT3*THETA(3) CL = EXP(MU_1+ETA(1)) That way you have only one OMEGA. This could be more flexible when expanding OMEGA for additional IIV in block format.

[NMusers] RE: Link different thetas to same omega using mu referencing

This looks like it would work - it seems to obey the rules around mu-referencing. You can simplify the $OMEGA by using SAME(3) Mike Michael J. Fossler, Pharm. D., Ph. D., F.C.P. VP, Quantitative Sciences Trevena, Inc mfoss...@trevenainc.com Office: 610-354-8840, e

[NMusers] Link different thetas to same omega using mu referencing

Hi Consider the case where we have a categorical (potentially time-varying) covariate named CAT that can take several values (e.g. 0,1,2,3). Let's say I want to model CL depending on this categorical covariate (where parameters are estimated on log-scale). A simple solution to this would be IF(

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