Mark:
I have looked at the initial theta evaluation which occurs when a lower and
upper bound are supplied, and no initial value (such as (0.001,,100.0), and it
seems that this method will only do a search using a First order objective
function evaluation. I will see if it can be expanded to FOC
thanks Bob
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
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