Dear Tingjie,
Your proposed objective function is based on least-squares distance. You
could also use the actual probability density:
objFunction = LOG(pnorm(Yobs - Ypred, sigma)) + LOG(pnorm(Para_i-Para_pop,
omega))
This allows more flexibility wrt parameter or residual variability
Dear NMusers,
I have two questions about the mathematical details on POSTHOC estimation in
NONMEM. How does NONMEM actually do when doing POSTHOC ($EST METHOD=0
MAXEVEL=0) to get ETAs? I assume but not for sure there is an objective
function to be minimized, somewhat like:
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