Matt:
The NPDE and NPD systems in NONMEM are described in the nm744.pdf manual (
https://nonmem.iconplc.com/nonmem744 ), pages 70-75, and follow along the work
of Comet, Brendel, Ngyuen, Mentre, etc. The NPDE R package is not used within
NONMEM.
Robert J. Bauer, Ph.D.
Senior Director
Pharmaco
Hi everyone,
As an aside, nlmixr's upcoming release (that supports censoring) simulates
a value using a truncated normal based on the ipred, variance at that point
and the censoring column to produce an observation. This observation is
used to calculate RES, WRES, CWRES. It is flagged so you can
