RE: [NMusers] relation of numerical error to gfortran?

2022-03-31 Thread Bill Denney
Hi Tong, The general issue of floating point instability is generally a problem for models that are hard to fit (3 days with full parallelization sounds hard to fit). It’s discussed in the intro7.pdf document in section I.70, “Stable Model Development for Monte Carlo Methods”. Given that you

[NMusers] relation of numerical error to gfortran?

2022-03-31 Thread Tong Lu
Hello All, Has anyone experienced numerical errors when using NONMEM with gfortran but not intel fortran? We have a complex PKPD model which gave us strage individual fitting with NM7.5.1 (compiled by gfortran) but not NM7.4.3 (compiled with intel fortran). When using NM7.5.1, there is an unexpec

[NMusers] Two PKPD permanent positions at Medicines for Malaria Venture

2022-03-31 Thread Nathalie Gobeau
Dear All, Medicines for Malaria Venture (MMV) is recruiting two PKPD Modelling and Simulation scientists to join our Translational Medicine team. The positions are based in Geneva, Switzerland (partially remote; currently Covid-remote). The seniority level (Manager/Associate Director) will depend