Hey, I would consider attending. I have no particular thoughts to share.
This year, I think I may wind up leading an initiative to develop a Shiny
App for data exploration (e.g. Dose-PK, Dose-PD, PKPD, with continuous,
binary, etc.). My vision is that we'd start small and gradually grow. So a
I wanted to follow up on the comments to Yaping's email.First, the
three probabilities below from the original code do in fact sum to 1.
P(1)=THETA(8)/100
P(2)=(1-THETA(8)/100)*THETA(9)/1000
P(3)=(1-THETA(8)/100)*(1-THETA(9)/1000)
Note that: P(2) + P(3) = 1-THETA(8)/100
And
can try running the estimation
step and see if you get the same estimates.
On Fri, 04 Mar 2011 23:03 -0500, Andy Stein andy.st...@gmail.com
wrote:
Thanks Scott. Cleaning up the dosing records is a great suggestion. And
so is removing the interaction term. I'm sad to say I don't even know
Hi,
I'm trying to solve an indirect response model in Nonmem where the drug
effect depends upon the dose, which can change every day. Currently, I'm
using the ADVAN6 routine, but because I have thousands of time points for
about a thousand patients, Nonmem is quite slow. I thought that in
...@globomaxnm.com]
*On Behalf Of *Andy Stein
*Sent:* Friday, March 04, 2011 10:51 AM
*To:* nmusers@globomaxnm.com
*Subject:* [NMusers] Speeding up code with explicit, piecewise ODE
solutions
Hi,
I'm trying to solve an indirect response model in Nonmem where the drug
effect depends upon
