Dear Palang,
Thanks for sharing your experience.
It seems you are facing a case of informative drop-out.
It may be valuable to model it indeed, in order to maximize the information
supporting your model and avoid a bias after 3 months based on
non-randomly remaining patients when determining whe
Dear Pavel,
Yes there is, one was published online just recently:
Lacroix BD, Friberg LE, Karlsson MO.
Evaluation of IPPSE, an alternative method for sequential population PKPD
analysis.
J Pharmacokinet Pharmacodyn. 2012 Jan 21.
In addition to presenting the 2 methods you're referring to, fixing
p
Dear Michael,
As you point out the truncation happens only for the output, so the correct
identification delimitation was taken into account during the NONMEM
process, however postprocessing needs make the output step critical and
this truncation undesirable.
The way to allow more digits to be re
lodie
Elodie L. Plan, PharmD, MSc, PhD student
Uppsala Pharmacometrics Research Group
From: Elodie Plan [mailto:elodie.p...@farmbio.uu.se]
Sent: Thursday, February 10, 2011 1:03 PM
To: 'nmusers@globomaxnm.com'
Subject: Uppsala Pharmacometri
Elodie L. Plan, PharmD, MSc, PhD student
Uppsala Pharmacometrics Research Group
From: Elodie Plan [mailto:elodie.p...@farmbio.uu.se]
Sent: Thursday, January 20, 2011 12:06 AM
To: 'nmusers@globomaxnm.com'
Subject: UPSS, Uppsala Pharmaco
Dear all,
The Uppsala Pharmacometric Research Group is happy to invite PhD students
from all around the world to their summer school.
DATES: 8-19 August 2011
PLACE: Uppsala, Sweden
INTENDED FOR: PhD students
PREREQUISITES: Intermediate NONMEM skills, analysis problem to bring
FEES: Free
Dear Paolo,
Thanks for this interesting NMusers thread.
I think the order you are describing really makes sense in theory, for the
reasons you describe, but in brief because it seems covariates should be
incorporated on a model already fully developed structurally and
statistically, so this inclu
+46 18-471 4003
From: marco.campi...@merckserono.net [mailto:marco.campi...@merckserono.net]
Sent: Friday, March 05, 2010 1:41 PM
To: Elodie Plan
Cc: alindauer-resea...@ferrergrupo.com; nmusers@globomaxnm.com;
owner-nmus...@globomaxnm.com
Subject: RE: [NMusers] Meta-analysis with Nonmem
Dear Andreas,
An approach you may consider is to model both the standard deviation and the
average as dependent variables:
SD=THETA(1)*EXP(ETA(1))
AV=(THETA(2)+DOSE*THETA(3))*EXP(ETA(2))
SESD=SD/(2*(N-1)**.5)
SEAV=SD/N**.5
IF(FLAG.EQ.0) THEN
Y = SD+SESD*EPS(1)
ELSE
Y = AV+SEAV*
Dear Tom and all,
I work with the code provided in the html help for NM7 and it successfully
estimates autocorrelation between observations; I just want to point out
what appeared to be a typo to me: " IF (NEWIND.LE.2) I=0 should be " IF
(NEWIND.NE.2) I=0, and to share that to my experience
Dear Nick,
I agree, it must be "remembered" somewhere that log(R) is forbidden, because
the simple following trick works (but won't once every 2 billion times, when
0 is picked):
IF (ICALL.EQ.4) THEN
T=0
N=0
DO WHILE (T.LT.1)
CALL RANDOM (2,R)
RA=R
Hi Nele,
About the technical issue, just change the order of your etas (2 and 3) in
order to have the 0 FIX at the place of cov1-3, this gives you what is
called a band matrix.
Hope it will help!
Best regards,
Elodie
Elodie L. Plan, PharmD, MSc,
Hi Ethan,
You can replace your initial values by your final estimates and set MAXEVAL
to 0 (and rerun, but this will be shorter).
Best regards,
Elodie
Elodie L. Plan, PharmD, MSc,
PhDstudent
***
Depar
Dear Ethan,
Perl-speaks-NONMEM (PsN) is a free program developed by Uppsala Research
Pharmacometrics group. We recently added a module performing Stochastic
Simulations followed by re-Estimations (SSE). The purpose is to investigate
aspects related to simulation or estimation methods, models, s
model.
I hope this helps,
Elodie
Elodie Plan, PharmD, MSc,
PhDstudent
*
Div. of Pharmacokinetics and Drug Therapy,
Department of Pharmaceutical Biosciences,
Faculty of Pharmacy, Uppsala University
PO
15 matches
Mail list logo
