Re: [NMusers] Estimation method for ETAs with POSTHOC

: myHessian <- hessian(objFunction, etaEstimates) FIM <- -1 * myHessian # Officially E(Hessian), but not necessary when using numeric methods myCovMatrix <- solve(FIM) Good luck! Kind regards, Ruben Faelens On Fri, May 5, 2017 at 2:17 PM Guo, Tingjie wrote: > Dear NMusers, &g

Re: [NMusers] Allometric scaling of renal clearance with estimated glomerular filtration rate

complicate things even more, depending on your viewpoint. Best regards Ruben Faelens Op di 5 dec. 2017 18:24 schreef : > Dear all, > > > > I am wondering what your thoughts are on the allometric scaling of > clearance of renally extreted drugs, where we have estimation

Re: [NMusers] [Suggest] NONMEM adds UTF-8 support for csv files

regards, Ruben Faelens On Wed, Jun 6, 2018 at 12:04 AM Mark Tepeck wrote: > Hi Joe and Sebastien, > > > Thank you for your feedback. Microsoft software is surely not my favorite > platform; However, I have to stick with MS due to the policy for the > organization computer I use.

[NMusers] Context-free lexer for NM-TRAN

xer_hack ) I assume building a parser for NM-TRAN was already done in the DDMoRe project, but I failed to find the source code... Kind regards, Ruben Faelens

Re: [NMusers] Context-free lexer for NM-TRAN

Tim > > > > *Tim Bergsma, PhD* > > Associate Director > > Certara Strategic Consulting > > [image: image001.png] > > m. 860.930.9931 <(860)%20930-9931> > > tim.berg...@certara.com > > > > *From:* owner-nmus...@globomaxnm.com *On > Behalf Of *

Re: [NMusers] Context-free lexer for NM-TRAN

ollaborating on the parser (can > you create a GitHub project for it)? Why ANTLRv3 instead of v4? Do you > have a way to get an ANTLR parse tree into R? > > > > Thanks > > > > Bill > > > > *From:* owner-nmus...@globomaxnm.com *On > Behalf

Re: [NMusers] Context-free lexer for NM-TRAN

hat would be the most reasonable implementation objective to > achieve the major outcomes. For example, having an autochecking CLI tool > for grammar errors vs a tool for updating parameters, vs a tool to > integrate with developer tools such as rstudio/vscode etc. > > Would al

Re: [NMusers] FW: Nonmem License High Availability

ould also not like it if Nonmem needs an internet connection to run, or would stop running when eg I change my hard drive. A similar system was briefly in place for Simulo, and was quickly adapted because of all the annoyances and hassle. Best regards, Ruben Faelens Op zo 2 sep. 2018 20:34 schree

Re: [NMusers] Sample distribution of etas

MCMC, sampled from the individual log-likelihood (which may not be normal-distributed). See http://monolix.lixoft.com/tasks/conditional-distribution/ for more information. I am not aware of similar functionality for NONMEM. Best regards, Ruben Faelens Op wo 13 mrt. 2019 13:41 schreef Tingji

Re: [NMusers] Microsoft MPI

Hi Mark, Last time I tried this (2016, Windows 8 64-bit), NONMEM needed some convincing: 1) You have to copy over the right object files from Microsoft MPI into the NONMEM mpi link directory mpi\mpi_wini; _and_ change the nmfe compiler call to include the right Microsoft MPI libraries. This should

Re: [NMusers] Microsoft MPI

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[NMusers] Algebraic equations and IOV

ng PK concentration using algebraic equations with IOV?* This is important for numerical validation between my framework and NONMEM / Monolix. Best regards, Ruben Faelens

Re: [NMusers] User defined likelihood function in POSTHOC estimation

Hi Tingjie, You used METHOD=COND LAPLACE in the default posthoc estimate. Whether INTERACTION is implied depends on your version of NONMEM. Could you check? I do not entirely understand the following section: $ERROR IPRED = F ; Predicted DV ADDI = 5.76 ; Variance of additive error PROR = 0.039601

Re: [NMusers] cumulative AUC

Hi Sam, Can't you simply dose with evid=4 (reset) into your auc compartment (cmt=4)? Op vr 8 nov. 2019 19:09 schreef Sam Liao : > Dear nmusers, > > I have a question how to reset cumulative AUC in a $DES model, where > DADT(4) is set up as cumulative AUC of C1. > > Because the study is a four w

Re: [NMusers] AMD vs Intel

Hi all, The Intel fortran compiler has a switch - fp-strict that switches off numerical optimization. See also https://software.intel.com/sites/default/files/comment/1721462/03-fp-consistency-2012.pdf Op ma 18 nov. 2019 18:42 schreef Leonid Gibiansky : > Thanks Bob and Peter! > > The model is qu