[NMusers] Test2

Test2 This message and any attachment are confidential and may be privileged or otherwise protected from disclosure. If you are not the intended recipient, you must not copy this message or attachment or disclose the contents to any other person. If you have received this transmission in erro

[NMusers] Test

This message and any attachment are confidential and may be privileged or otherwise protected from disclosure. If you are not the intended recipient, you must not copy this message or attachment or disclose the contents to any other person. If you have received this transmission in error, pl

[NMusers] Two Positions at Merck Pharmacometric Department in Darmstadt and Lausanne

t the careers pages on https://career012.successfactors.eu/career?company=merckgroup and enter the Requisition ID: 151627. With best regards, Pascal Girard Director, Head of Pharmacometry Merck Merck Institute for Pharmacometrics, EPFL Innovation Park - Building I, CH-1015 Lausanne, Switzerland

Re: [NMusers] ASCO and pharmacometrics

el, Switzerland Phone: +41 61 324 4676 phil.l...@novartis.com<mailto:phil.l...@novartis.com> From: owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com> [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Pascal Girard Sent: 06 April 2016 10:39 To: Naoto Hayashi; jgre...@btco

RE: [NMusers] ASCO and pharmacometrics

Dear Naoto, In the past, Rene Bruno got one poster accepted with discussion at ASCO. He is our ”champion” ! I got one accepted on model for Exp-Tumor Size – OS at European Cancer Congress 2013 . But I can tell you that a medical writer rewrote it entirely and it took 1 month to get it reviewed

RE: [NMusers] forest plots in Xpose?

Dear All, Thanks all for your replies. I will not reply to each. Just to say that of course I know that forest plots come from Meta Analysis, which by the way may be already familiar to clinicians. It has been advocated by FDA to report DDI see (Menon-Andersen D, Yu B, Madabushi R, Bhattaram

[NMusers] forest plots in Xpose?

from the CRAN. Has anyone developed such a package? With best regards / Mit freundlichen Grüßen / Cordialement / 祝好 / よろしくお願いします Pascal Pascal Girard Director, Pharmacometry Merck Serono | Global Early Development "Merck – Living Innovation" Merck Institute for Pharm

[NMusers] Quantitative Pharmacology Positions @ Merck Serono

cal aspects of M&S in drug development * Is enthusiastic, self-motivated and has good communication skills, and at ease in working in a dynamic matrix organization; is a team-player. Communicate technical details effectively with scientists and clinicians colleagues With best reg

[NMusers] Merck Serono: Manager in Pharmacometrics position

r. Communicate technical details effectively with scientists and clinicians colleagues To apply please visit the careers pages on https://career012.successfactors.eu/career?company=merckgroup and enter the following Requisition ID 41221 for the manager position in Darmstadt. With best regard

[NMusers] RE: Standard errors of estimates for strictly positive parameters

Dear Aziz, NM does not return the asymptotic SE of THETA(1) in model 1 on the log-scale. So I would use model 2. With best regards / Mit freundlichen Grüßen / Cordialement Pascal From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Chaouch Aziz Sent: 11 Febru

[NMusers] Merck Serono: Manager and Senior Scientist in Pharmacometrics job posting

nd enter the following Requisition ID 41221 for the manager position in Darmstadt or Requisition ID 59283 for the Senior Scientist in Lausanne or Darmstadt. With best regards, Pascal Girard Director, Pharmacometry Merck Serono | Global Early Development "Merck - Living Innovat

[NMusers] Test

Test Pascal Girard This message and any attachment are confidential and may be privileged or otherwise protected from disclosure. If you are not the intended recipient, you must not copy this message or attachment or disclose the contents to any other person. If you have received this

[NMusers] Senior Scientist M&S Position at Merck Serono

layer. Communicate technical details effectively with scientists and clinicians colleagues To apply please visit the careers pages on https://career012.successfactors.eu/career?company=merckgroup and enter the following Requisition ID 41221. With best regards, Pascal Girard Director,

RE: [NMusers] Bootstrap, re-using inital model run results

Dear Anuhbia, Since bootstrap is performed to replace the estimation of precision that is performed in the $COV step, you definitively do not need the $COV option when you do a bootstrap. Then CI are obtained based on the quantiles of the bootstrap estimates. Kind regards, Pascal Girard

Re: [NMusers] Different EBE estimation between original and enriched dataset with MDV=1

the one with the dummy points. > > 4) I decided to redo the grid with only one dummy point every 1/4 of > > time unit. The result was less dramatic, but still for most of my > > individuals the EBEs predictions were diverging from the original ones > > computed without

RE: [NMusers] Different EBE estimation between original and enriched dataset with MDV=1

=1 to your original dataset you sometimes get very > different EBEs ? Are there cases/models/ADVAN where the problem is > likely to happen? Is their a way to fix it it in NONMEM other than the > trick I used? > > Thanks for your replies! > > Kind regards, > > Pasca

[NMusers] Different EBE estimation between original and enriched dataset with MDV=1

sometimes get very different EBEs ? Are there cases/models/ADVAN where the problem is likely to happen? Is their a way to fix it it in NONMEM other than the trick I used? Thanks for your replies! Kind regards, Pascal Girard, PhD pascal.gir...@merckgroup.com Head of Modeling & Simula

RE: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid

ways got the "Fatal Error: Record SIZES is not valid" message. I looked into Help guide viii (pp 166-167 and 463-464) but did not find any relevant information how to set $SIZES. What would be your suggestion? Thanks again for your help, because it's highly frustrating not being

Re: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid

;s highly frustrating not being able to use the multi-cores when you have such long runs. Kind regards Pascal Girard, PhD pascal.gir...@merckgroup.com Head of Modeling & Simulation - Oncology Global Exploratory Medicine Merck Serono S.A. · Geneva Tel: +41.22.414.3549 Cell: +

RE: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid

Thanks again for your help, because it's highly frustrating not being able to use the multi-cores when you have such long runs. Kind regards Pascal Girard, PhD pascal.gir...@merckgroup.com Head of Modeling & Simulation - Oncology Global Exploratory Medicine Merck Serono S.

RE: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid

not find any relevant information how to set $SIZES. What would be your suggestion? Thanks again for your help, because it's highly frustrating not being able to use the multi-cores when you have such long runs. Kind regards Pascal Girard, PhD pascal.gir...@merckgroup.com Head of Modeling &

[NMusers] Error files when using multicore runs and psn

bove? Thank you for your help, Kind regards Pascal Girard, PhD pascal.gir...@merckgroup.com Head of Modeling & Simulation - Oncology Global Exploratory Medicine Merck Serono S.A. · Geneva Tel: +41.22.414.3549 Cell: +41.79.508.7898 This message and any attachment are confidential and may be

Re: [NMusers] How to model delayed count data due to time needed to form an event

, Liu J, Qiu R, Frame B, Miller R. Exposure-response analysis for spontaneously reported dizziness in pregabalin-treated patient with generalized anxiety disorder. Clin Pharmacol Ther. 2008 Jul;84(1):127-35. Kind regards / Mit freundlichen Grüßen / Bien cordialement Pascal Girard, PhD pascal.gir

[NMusers] EOP2A experience?

share some of this experience. Thank you in advance for your replies. Kind regards, Pascal Girard This message and any attachment are confidential and may be privileged or otherwise protected from disclosure. If you are not the intended recipient, you must not copy this message or attachment or

[NMusers] M&S position in oncology at Merck Serono

nd software (MONOLIX, Bayesian software, TS2, optimal pop PK/PD designs ?) would be an asset, together with knowledge of R/Splus, SAS or Matlab programming languages. Interested candidates should send their application to Martin Baltes, Human Resources - Merck KGaA - Darmstadt (martin.bal...@merck.de).