-nmus...@globomaxnm.com] On
Behalf Of Diane-Charlotte Imbs
Sent: Tuesday, April 21, 2015 11:47 AM
To: Leonid Gibiansky
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] variation of time values in output data
Thank you, Leonid, for your answer but you can see (below) it’s not a rounding
issue
I think the problem is the DATE column. If this column is called DATE also in
$INPUT it will be interpreted as a date and NONMEM will adjust your time
according to that date, adding 24 hours.
Even though you put =DROP on this column NM will recognise DATE. Call is
something else unless you want
: [NMusers] variation of time values in output data
Thank you, Leonid, for your answer but you can see (below) it’s not a rounding
issue ; there are udge variations of time ?!!!
INPUT FILE :
ID DATE TIME DV AMT RATE
MDV EVID
3
it could be rounding issue when the precision of the TIME in the data
file exceeds the precision of the TIME in the output of the table. You
could increase precision of the output using format statement (see
manual). Other than that, NONMEM should not change TIME variable.
Leonid
Dear nonmem users,
We used the option “-2 RATE” of NONMEM (actual rate of infusion is
unknown): within the control stream:
D1=THETA(1)
Moreover, since several infusions are given to the same patients, we have
added an inter-occasion variability on D1 (see code below)*
We obtained nice fit