From: owner-nmus...@globomaxnm.com on behalf of
Matthew Fidler
Sent: Saturday, September 5, 2020 10:17 AM
To: Bauer, Robert
Cc: nmusers@globomaxnm.com
Subject: [External] Re: [NMusers] M3 method - WRES, and CWRES
Thank you Bob,
The NPDE 2.0 manual discusses the methods
;
> *From:* owner-nmus...@globomaxnm.com *On
> Behalf Of *Matthew Fidler
> *Sent:* Thursday, September 3, 2020 6:08 AM
> *To:* Jeroen Elassaiss-Schaap (PD-value B.V.)
> *Cc:* Bill Denney ; Mu'taz Jaber <
> jaber...@umn.edu>; nmusers@globomaxnm.com
> *Subject:* Re
Fidler
Sent: Thursday, September 3, 2020 6:08 AM
To: Jeroen Elassaiss-Schaap (PD-value B.V.)
Cc: Bill Denney ; Mu'taz Jaber
; nmusers@globomaxnm.com
Subject: Re: [NMusers] M3 method - WRES, and CWRES
Hi everyone,
As an aside, nlmixr's upcoming release (that supports censoring) simulates a
Hi everyone,
As an aside, nlmixr's upcoming release (that supports censoring) simulates
a value using a truncated normal based on the ipred, variance at that point
and the censoring column to produce an observation. This observation is
used to calculate RES, WRES, CWRES. It is flagged so you
Hi Mutaz, Bill,
It might be useful to use NPDEs, as discussed in
https://www.cognigen.com/nmusers/2019-February/7376.html; the whole
thread is worthwhile reading. NPDEs can be calculated also for BQL values.
Bill -thanks for pointing to excellent post of Matt! I would take as
most
Hi Mutaz,
Matt Hutmacher described it well here:
https://www.cognigen.com/nmusers/2010-April/2448.html
A very brief summary of his excellent post is that subjects with a
combination of censored (BLQ) an uncensored (above the LLOQ and below the
ULOQ) will be biased in their reporting of CWRES
