RE: [NMusers] RE: Link different thetas to same omega using mu referencing

2016-04-14 Thread Leander, Jacob
; nmusers@globomaxnm.com Subject: Re: [NMusers] RE: Link different thetas to same omega using mu referencing Hi Jacob, Yes, THETA(4) would represent the typical value (before exponentiation). In summary, writing your covariate code after the definition of MU should circumvent the time-varyi

Re: [NMusers] RE: Link different thetas to same omega using mu referencing

2016-04-13 Thread Emmanuel Chigutsa
; ; "'Sadler, Brian'" ; "nmusers@globomaxnm.com" Sent: Wednesday, April 13, 2016 2:00 PM Subject: RE: [NMusers] RE: Link different thetas to same omega using mu referencing #yiv8370814822 #yiv8370814822 -- _filtered #yiv8370814822 {font-family:Helvetica;panose-1:2 11 6 4

Re: [NMusers] RE: Link different thetas to same omega using mu referencing

2016-04-13 Thread Emmanuel Chigutsa
om Sent: Wednesday, April 13, 2016 11:44 AM Subject: RE: [NMusers] RE: Link different thetas to same omega using mu referencing #yiv7090570546 #yiv7090570546 -- _filtered #yiv7090570546 {panose-1:2 4 5 3 5 4 6 3 2 4;} _filtered #yiv7090570546 {font-family:Calibri;panose-1:2 15 5 2 2 2

RE: [NMusers] RE: Link different thetas to same omega using mu referencing

2016-04-13 Thread Bob Leary
: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Rupert Austin Sent: Wednesday, April 13, 2016 11:44 AM To: 'Sadler, Brian'; nmusers@globomaxnm.com Subject: RE: [NMusers] RE: Link different thetas to same omega using mu referencing I’m not sure th

RE: [NMusers] RE: Link different thetas to same omega using mu referencing

2016-04-13 Thread Rupert Austin
I’m not sure that Brian’s suggestion is acceptable due to the following constraint I quote from one of the NONMEM manuals: “Time dependent covariates cannot be part of the MU_ equation” If CAT is time-varying (as suggested by Jacob) then “MU_1 = CAT1*THETA(1) + CAT2*THETA(2) + CAT3*THETA(