sekfung opened a new issue #5733:
URL: https://github.com/apache/apisix/issues/5733


   ### Issue description
   
   **error log**
   ```log
   [error] 48#48: *2240177 connect() failed (111: Connection refused) while 
connecting to upstream
   
   [lua] balancer.lua:327: run(): failed to pick server: failed to find valid 
upstream server, all upstream servers tried while connecting to upstream
   
   ```
   
   It can work sometimes, I try to increase times of retry for the route, but 
it can't solve this problem at all.
   
   
   ### Environment
   
   - apisix version (cmd: `apisix version`): 2.10.1
   - OS (cmd: `uname -a`): Linux apisix-6df8748bf6-v5hnb 4.14.105-19-0022
   - OpenResty / Nginx version (cmd: `nginx -V` or `openresty -V`): 
openresty/1.19.3.1
   - etcd version, if have (cmd: run `curl 
http://127.0.0.1:9090/v1/server_info` to get the info from server-info API): 
etcd Version: 3.4.16
   - apisix-dashboard version, if have:
   - the plugin runner version, if the issue is about a plugin runner (cmd: 
depended on the kind of runner):
   - luarocks version, if the issue is about installation (cmd: `luarocks 
--version`):
   


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