I'm a bit confused by this.  Running different instances/ini files suggests 
that you're doing a multiple, differential, deployment.  Using a database 
for configuration suggests a multi-tenant setup.

FWIW, In my experience dealing with different environments for deployment, 
I've used a mixture of:
   • .ini scripts that are generated by Fabric and 
   • hooking into the ApplicationCreated event
   • running a setup routine in the application's own initialization

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