I am pleased to announce the release of xlwings v0.4.0: 

The most important update with this release was made on Windows: The 
methodology used to make a connection to Workbooks has been completely 
replaced. This finally allows xlwings to reliably connect to multiple instances 
of Excel even if the Workbooks are opened from untrusted locations (network 
drives or files downloaded from the internet). This gets rid of the dreaded 
"Filename is already open..." error message that was sometimes shown in this 
context. It also allows the VBA hooks ("RunPython") to work correctly if the 
very same file is opened in various instances of Excel.

Check the Release Notes for full details: 
http://docs.xlwings.org/whatsnew.html 

About xlwings: 
xlwings is a BSD-licensed python library that makes it easy to call python from 
Excel and vice versa: 

Interact with Excel from python using a syntax that is close to VBA yet 
pythonic. 
Replace your VBA macros with python code and still pass around your workbooks 
as easily as before. 
xlwings fully supports NumPy arrays and Pandas DataFrames. 

It works with Microsoft Excel on Windows and Mac. 

http://xlwings.org
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