What version of pywin32 are you running ?
You might want to try upgrading to build 204
if you haven't already. There was a bug where
a toolbar registry key was written multiple times,
which eventually fills up the registry and slows
the machine down, along with some
strange window behaviour.
I read that Tkinter and Python IDEs (PythonWin and Idle at least) makes
for a bad mix in execution mode because they're fighting for the event
loop, but this mode is usefull to use the debugger.
But to the point of breaking something elsewhere than in memory ???
(Shutting down and rebooting the