Thanks to all. It was just programming error. The following now works. Essentially, to impose non-negative restrictions I estimated the natural logs of two parameters and then do exponential transformation to uncover the parameters, with mathematical transformation (delta method) for their standard errors.

I believe deltaMethod {car} does that sort of things. I have yet to look up if it does that for nonlinear regression object. But since the exponential transformation is a simple transformation (with a derivative equal to itself), I tried to program my own. Thanks to all.

> obj<-cbp11.pooled
> j<-grep("gamma",names(obj$est),value=TRUE); j
[1] "log.gamma1" "log.gamma2"
> obj$estimate[j]
log.gamma1 log.gamma2
  -1.82378   -1.11313
> obj$stat$vb[j,j]
           log.gamma1 log.gamma2
log.gamma1  0.0842252  0.0138778
log.gamma2  0.0138778  0.0793592
> mydelta <- function(obj,j){
+ # *******************************************
+ # Delta method for exponential transformation
+ # *******************************************
+   b<-obj$estimate[j]
+   v<-obj$stat$vb[j,j]; v
+   gamma<-exp(b)
+   db<-gamma
+   vgamma<-db^2*v
+   sgamma<-sqrt(diag(vgamma))
+   t<-gamma/sgamma
+   df<-n<-obj$stat$n
+   p<-2*(1-pt(abs(t),df))
+   list(gamma=gamma,sgamma=sgamma,b=b,t=t,p=p)
+ }
> v<-mydelta(obj,j)
> v$b
log.gamma1 log.gamma2
  -1.82378   -1.11313
> v$gamma
log.gamma1 log.gamma2
  0.161414   0.328529
> v$sgamma
log.gamma1 log.gamma2
 0.0468449  0.0925490
> v$t
log.gamma1 log.gamma2
   3.44571    3.54978
> v$p
 log.gamma1  log.gamma2
0.000574108 0.000388996
>

On 9/9/2022 8:39 PM, Ebert,Timothy Aaron wrote:

If t = 1/sqrt(v[2,2]) and there is no code to change the value of v[2,2] and no 
code to change to a different cell why would you get two different values?

One approach to debugging is to make a small example and see if the code output 
matches (line-by-line) the output you get from doing a manual calculation. If 
they do not match you at least know where to start looking for a problem. Hand 
calculation can use pencil and paper or Excel or other tools. It is a tedious 
task but very effective.

Tim

-----Original Message-----
From: R-help <r-help-boun...@r-project.org> On Behalf Of Ivan Krylov
Sent: Friday, September 9, 2022 5:03 AM
To: Steven T. Yen <st...@ntu.edu.tw>
Cc: R-help Mailing List <r-help@r-project.org>
Subject: Re: [R] Help with a simple subroutine

[External Email]

В Fri, 9 Sep 2022 16:46:00 +0800
"Steven T. Yen" <st...@ntu.edu.tw> пишет:

I am expecting the line  t<-gamma/sgamma to produce two different
values. But I confirm that it is doing tt<-gamma[1]/sgamma[1]
No, it just happens that gamma[1]/sgamma[1] is the same as gamma[2]/sgamma[2], 
subject to rounding errors:

+   gamma<-exp(b)
+   vgamma<-gamma^2*v[2,2]
+   sgamma<-sqrt(vgamma)
+   t<-gamma/sgamma
t = gamma / sgamma = gamma / sqrt(gamma^2 * v[2,2]) =
   = gamma / (abs(gamma) * sqrt(v[2,2])) = (given gamma = exp(b) > 0)
   = 1 / sqrt(v[2,2]).

--
Best regards,
Ivan

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