[R] Gene expression clustering using several dependent samples

2013-07-01 Thread Moritz Kebschull
Dear list. I am looking at a dataset comprised of Affy images from disease-affected tissue samples that I am trying to cluster. The problem is that we have 2+ biopsies per study subject, and I am not sure how to best account for their dependency. In contrast to cancer samples, these biopsies

Re: [R] Gene expression clustering using several dependent samples

2013-07-01 Thread James C. Whanger
Hello Moritz, You may want to take a look at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052263/ . DeSantis et al. (2009) identified different genomic profiles using a Bayesian Latent Class methodology. Best, James On Sun, Jun 30, 2013 at 2:47 PM, Moritz Kebschull mor...@kebschull.mewrote: