[R] multi-level cox ph with time-dependent covariates

Dear all, I would like to know if it is possible to fit in R a Cox ph model with time-dependent covariates and to account for hierarchical effects at the same time. Additionally, I'd like also to know if it would be possible to perform any feature selection on this model fit. I have a data set th

[R] multi-level cox ph with time-dependent covariates

Dear all, I would like to know if it is possible to fit in R a Cox ph model with time-dependent covariates and to account for hierarchical effects at the same time. Additionally, I'd like also to know if it would be possible to perform any feature selection on this model fit. I have a data set th

Re: [R] multi-level cox ph with time-dependent covariates

Your question has two levels: 1. What is the right model for this data 2. Can model __ be fit Wrt 2 and coxme: For a reliable fit you need to have more events than random effects. Thus for patient/tissue I would want to see multiple events per patient/tissue pair. This is statistical issue