[R] OT Futility Analysis

2006-02-17 Thread Kevin E. Thorpe
I beg your pardon if this is too off topic. I am posting here since I hope to find an R solution to my problem. Please indulge me while I give a little background about what I'm trying to do. I'm on a DSMB for a clinical trial. The Steering Committee for the trial has asked us to perform a futi

Re: [R] OT Futility Analysis

2006-02-21 Thread Spencer Graves
What does this particular Steering Committee think a "futility analysis" is? Do they have any particular reference(s)? What do you find in your own literature review? If it were my problem, I think I'd start with questions like that. Your comments suggested to me a confoun

Re: [R] OT Futility Analysis

2006-02-22 Thread Stephen A Roberts
Steve. > -Original Message- > From: [EMAIL PROTECTED] [mailto:r-help- > [EMAIL PROTECTED] On Behalf Of Spencer Graves > Sent: 22 February 2006 03:45 > To: Kevin E. Thorpe > Cc: R Help Mailing List > Subject: Re: [R] OT Futility Analysis > > What does th

Re: [R] OT Futility Analysis

2006-02-22 Thread Kevin E. Thorpe
Thank you Spencer and Steve for your helpful comments. If I may, I would like to elaborate on some of the points you raise. Stephen A Roberts wrote: > I would take the line that if they hadn't pre-specified any stopping > rules, the only reason to stop is safety or new external data. I > would be

Re: [R] OT Futility Analysis

2006-02-22 Thread Marc Schwartz (via MN)
On Wed, 2006-02-22 at 11:57 -0500, Kevin E. Thorpe wrote: > Thank you Spencer and Steve for your helpful comments. If I may, I > would like to elaborate on some of the points you raise. Kevin, I am not sure if you received any offlist replies to your post. Given the subject matter, I had conside