Hi Florian,
The problem here isn't actually chirality (since you don't have any chiral
centers specified). It's more that standard embedding can be tricky for
large molecules like this. The solution is general to switch to starting
the embedding from random coordinates.
ps = AllChem.ETKDGv2()ps.r
Dear all,
I encountered a problem with EmbedMultipleConfs which returns empty list for
some molecules (and for another molecules a few conformations when I don't add
Hs) I think both cases are linked since problems occur with high number of
rotatable bonds (more than 25). I tried to look for a
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