I have read yet another theory on this that ties it to various degrees of hypothyroidism. In hypothyroidism, cells are not able to clear toxins and byproducts of metabolism. People naturally become more hypo as they age. In the caveman days, humans got some amount of animal thyroid from their meet and it is estimated that it was about equivalent to 1/4 grain a week. This could offset it if it is playing a role in the buildup.
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