I am sure that you have heard that the nanoparticle versions of some
commonly use substances have been shown to have a significantly
increased toxicity. Part of the problem is that the nanoparticles can be
absorbed through the skin and accumulate in the tissues of the body.
Zinc oxide is a case in point. Several links are provided below as an
example but are not discussed. It is not my intent to create a fear of
zinc oxide.  In fact, it has been found that coating zinc oxide
nanoparticles with dimethicone reduces or eliminates zinc oxide
nanoparticle absorption and so most topical lotions or creams containing
zinc oxide nanoparticles include dimethicone in the composition for this
purpose.

However, silver nanoparticles have been identified in the studies as
particularly harmful because of their high reactivity. Concerned about
the possible accumulation of silver particles in the brain, I had mostly
converted to using purely ionic silver. But based on the study I have
previously posted on, High Chemical Reactivity of Silver Nanoparticles
Toward Hydrochloric Acid, I don't think that is necessary since silver
nanoparticles do not survive the stomach's acid as particles. However it
may be prudent to use CS that is primarily ionic for nasal sprays and
nebulizing since any particles in the solution are not converted by
stomach acid.

I think that the study, High Chemical Reactivity of Silver Nanoparticles
Toward Hydrochloric Acid, is of ground breaking importance. It
completely changes the heretofore understanding of how colloidal silver
particles act in vivo. 


 - Steve N


http://www.merid.org/ndn/more.php?articleID=1905&search=%2Fndn%2Farchive
.php%3FdoSearch%3D1%26food_and_agriculture%255B%255D%3DFood&scorePrecent
=100
Toxicity of Nanoparticles: Zinc Oxide on the Brain

http://www.azonano.com/news.asp?newsID=18214
Zinc Oxide Nanoparticles Used in Suncreens are Toxic to Colon


Studies that discuss silver nanoparticle toxicity:

http://www.hindawi.com/journals/jt/2009/754810.html
On the Toxicity of Therapeutically Used Nanoparticles: An Overview

http://toxsci.oxfordjournals.org/cgi/content/full/88/2/412
In Vitro Cytotoxicity of Nanoparticles in Mammalian Germline Stem Cells



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