Hi,

I find that `UniqueConstraint` from `sqlachemy` and 
`op.create_unique_constraint` by `alembic`, it cannot handle multiple 
columns that contain null values.

I saw we can solve using  SQL commands via some tricky ways like creating 
unique index and coalesce, do we have some ways using `sqlachemy` instead 
of directly using `SQL` to solve this issue?

Thanks!

Lydia

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