As of 0.7.6 sympy uses an LRU cache by default.  cachey looks interesting 
but I think the "nbytes" may be challenging to compute for sympy objects 
and operations. 

There was some discussion of adopting a similar caching policy a while 
ago: https://github.com/sympy/sympy/issues/6321


On Wednesday, August 19, 2015 at 10:23:57 PM UTC-6, Denis Akhiyarov wrote:
>
> Once I had some issues with cache in sympy and recently noticed this nice 
> idea cachey. Seems to be a perfect fit for sympy? In short the idea is to 
> cache based on size and computation effort using a simple formula.
>
> http://matthewrocklin.com/blog/work/2015/08/03/Caching/
>
> The goal is to keep the cache of limited size, but pick/keep the cached 
> items wisely.
>
> score+=compute_time/nbytes*(1+e)^t
>
>

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