A PhD position is open for applications in the Department “Theoretical Bioinformatics” at the German Cancer Research Centre (DKFZ), Heidelberg, Germany. The project arises from the challenges of systems biology, which is a growing area combining biological experimentation with computational analysis and modelling. The PhD is concerned with the development of novel methods for inferring gene regulatory and signalling pathways from the time-course biological data. The methodological framework is expected to be probabilistic graphical modeling, in particular Bayesian modeling. Dynamic Bayesian networks were already applied hereto, however the main challenges remain to be addressed: the short time courses, the switching non-stationary behaviour of the genes/proteins, the sparsity of data. The PhD will be funded by the Helmholtz Alliance on Systems Biology within the project “Systems biology of cancer signalling”. This gives the PhD student a unique opportunity to work in a large interdisciplinary environment e.g. in collaboration with the systems biology centre BIOQUANT at the University of Heidelberg and other research institutions.
The goal is to complete the PhD thesis within 3 years.
We are looking for highly motivated candidates graduated in Statistics, Mathematics or Computer Science. A background in machine learning, Bayesian networks and good programming skills will be of advantage. The starting date is flexible. The applications will be considered until the position is filled. Please send your application with the complete Curriculum Vitae, the academic record (including courses and grades) and contact details of at least one person who may be asked for reference to: s.bulashev...@dkfz.de.
If you know a suitable candidate please fill free to distribute this e-mail.
Thanks for your attention,
 Dr. Svetlana Bulashevska
“Theoretical Bioinformatics”
German Cancer Research Centre (DKFZ)
Heidelberg, Germany

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