Mistake: This was an upgrade to 19.10 where the problem was seen.
Subsequent upgrade to 20.04 has completely removed the issue.
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https://bugs.launchpad.net/bugs/1876654
Title:
After up
Public bug reported:
Any application that results in a period of intense disk activity causes
the mouse and keyboard to become unresponsive. When copying large files
the mouse will respond for a brief period, a few microseconds, moving
across the screen, but then won't respond for 10-15 seconds.