"in the last decade. The world went from connected to hyperconnected", so Woodrow C. Monte methanol-formaldehyde paradigm, being true, is spreading and evolving exponentially: Thomas L. Friedman: Dan Novak: Rich Murray 2013.01.31 http://rmforall.blogspot.com/2013/01/in-last-decade-world-went-from.html
so this post illustrates and is this benign collaborative exponential creativity... comrade Dan Novak, thanks for resonating so well with what I wanted to alert family and friends about -- maybe a new global economy has to always guarantee free all basic needs, including all education and information collaboration access, while inviting all kinds of people and their networks to compete constructively at anything that serves themselves and others -- the work-play-service itself is its own daily reward -- what I am doing re methanol-formaldehyde toxicity, being a good example -- I just started posting free conscientious reviews 14 years ago about aspartame research, anticipating exponential world change via the Net -- attracting the probable history since fall 2007 where I am collaborating closely with Woodrow C. Monte, whose breakthrough methanol-formaldehyde paradigm expands the game from aspartame to all methanol sources and dozens of major diseases, from Alzheimer's to autism, which will generate trillions of dollars of benefit as the paradigm expands and evolves exponentially -- suddenly, the evolving biological measurement technology makes the scientific confirmation a trivial, rapid one-expert action -- in this case the process of applying the paradigm is remarkably simple, cheap, safe, effective for treatment and prevention -- just avoid all methanol... within the fellowship of service, Rich On Thu, Jan 31, 2013 at 10:18 AM PST, Dan Novak < > wrote: > > -----Original Message----- > From: URI General Discussion List [mailto:theforu...@listserv.uri.edu] On Behalf Of Dan Novak > Sent: Wednesday, January 30, 2013 12:36 PM > To: theforu...@listserv.uri.edu > Subject: lotta Q's! > > Good Morning! -- DN > > January 29, 2013, The New York Times > > It’s P.Q. and C.Q. as Much as I.Q. > > By THOMAS L. FRIEDMAN > President Obama’s first term was absorbed by dealing with the Great Recession. I hope that in his second term he’ll be able to devote more attention to the Great Inflection. Dealing with the Great Recession was largely about “Yes We Can” — about government, about what we can and must do “together” to shore up the safety nets and institutions that undergird our society and economy. Obama’s Inaugural Address was a full-throated defense of that “public” side of the unique public-private partnership that makes America great. But, if we’re to sustain the kind of public institutions and safety nets that we’re used to, it will require a lot more growth by the private side (not just more taxes), a lot more entrepreneurship, a lot more start-ups and a lot more individual risk-taking — things the president rarely speaks about. And it will all have to happen in the context of the Great Inflection. What do I mean by the Great Inflection? I mean something very big happened in the last decade. The world went from connected to hyperconnected in a way that is impacting every job, industry and school, but was largely disguised by post-9/11 and the Great Recession. In 2004, I wrote a book, called “The World Is Flat,” about how the world was getting digitally connected so more people could compete, connect and collaborate from anywhere. When I wrote that book, Facebook, Twitter, cloud computing, LinkedIn, 4G wireless, ultra-high-speed bandwidth, big data, Skype, system-on-a-chip (SOC) circuits, iPhones, iPods, iPads and cellphone apps didn’t exist, or were in their infancy. Today, not only do all these things exist, but, in combination, they’ve taken us from connected to hyperconnected. Now, notes Craig Mundie, one of Microsoft’s top technologists, not just elites, but virtually everyone everywhere has, or will have soon, access to a hand-held computer/cellphone, which can be activated by voice or touch, connected via the cloud to infinite applications and storage, so they can work, invent, entertain, collaborate and learn for less money than ever before. Alas, though, every boss now also has cheaper, easier, faster access to more above-average software, automation, robotics, cheap labor and cheap genius than ever before. That means the old average is over. Everyone who wants a job now must demonstrate how they can add value better than the new alternatives. When the world gets this hyperconnected, adds Mundie, the speed with which every job and industry changes also goes into hypermode. “In the old days,” he said, “it was assumed that your educational foundation would last your whole lifetime. That is no longer true.” Because of the way every industry — from health care to manufacturing to education — is now being transformed by cheap, fast, connected computing power, the skill required for every decent job is rising as is the necessity of lifelong learning. More and more things you know and tools you use “are being made obsolete faster,” added Mundie. It’s as if every aspect of our lives is now being driven by Moore’s Law. This is exacerbating our unemployment problem. In their terrific book, “Race Against the Machine: How the Digital Revolution Is Accelerating Innovation, Driving Productivity, and Irreversibly Transforming Employment and the Economy,” Erik Brynjolfsson and Andrew McAfee of the Massachusetts Institute of Technology note that for the last two centuries it happened that productivity, median income and employment all tracked each other nicely. “So most economists have had this feeling that if you just boost productivity, the pie grows, and, in the long run, everything else takes care of itself,” explained Brynjolfsson in an interview. “But there is no economic law that says technological progress has to benefit everyone. It’s entirely possible for the pie to get bigger and some people to get a smaller slice.” Indeed, when the digital revolution gets so cheap, fast, connected and ubiquitous you see this in three ways, Brynjolfsson added: those with more education start to earn much more than those without it, those with the capital to buy and operate machines earn much more than those who can just offer their labor, and those with superstar skills, who can reach global markets, earn much more than those with just slightly less talent. Put it all together, he added, and you can understand, why the Great Recession took the biggest bite out of employment but is not the only thing affecting job loss today: why we have record productivity, wealth and innovation, yet median incomes are falling, inequality is rising and high unemployment remains persistent. How to adapt? It will require more individual initiative. We know that it will be vital to have more of the “right” education than less, that you will need to develop skills that are complementary to technology rather than ones that can be easily replaced by it and that we need everyone to be innovating new products and services to employ the people who are being liberated from routine work by automation and software. The winners won’t just be those with more I.Q. It will also be those with more P.Q. (passion quotient) and C.Q. (curiosity quotient) to leverage all the new digital tools to not just find a job, but to invent one or reinvent one, and to not just learn but to relearn for a lifetime. Government can and must help, but the president needs to explain that this won’t just be an era of “Yes We Can.” It will also be an era of “Yes You Can” and “Yes You Must.” Dan Novak 10:17 AM (10 hours ago) PST Thursday 2013.01.31 to me R Thanks, much enjoyed... The way I shared it with one list: D Subject: Cruising in the Aero-Bahamas... Good Morning! Sent by a friend who tracks avenues of innovation. "Hybrid" is the name we often give to a burgeoning innovation, like horseless carriage for instance. William Gibson: "The future is already here but isn't evenly distributed." What is called "luxury" is one of the first fronts or waves of material transmogrifs. One can assume that what is called "material" is the body or manifestation of another realm, whether that be called desire, consciousness, astral energy, or spiritual. Anyway, it's fun to look at the first reachings out of "imagination" (often cognitively diminunitized) as harb(r)inger. > highly practical Aeroscraft rigid skin airship 787 feet long, 234 foot size now floating in its hanger, to carry 500 tons to 12,200 feet at 100 knots/hour -- moves air in and out of internal tanks to control lift: Rich Murray 2013.01.30 http://rmforall.blogspot.com/2013/01/highly-practical-aeroscraft-rigid-skin.html You can subscribe at http://phys.org/news/ for free daily mailing of dozens of quality articles on world wide advances in science and technology -- today's issue was amazingly full of striking advances, including two at new universities in Singapore -- you, see, since the Net has exploded publicly to about 2 billion users since 1990, no genius is being left behind -- innovation is always exponential, my main interest at MIT in 1962-4 -- In 1990 the Internet had existed for only 7 years; just 3 million people had access to it worldwide -- 361 million by end of 2000 -- predicted to reach over 2,500 million users this year -- with far cheaper computers that are millions of times more powerful since 1990 -- while Net connection speeds have just risen to 54,000,000 bps in Hong Kong, up from 300 bps with Prodigy and America Online in 1992, a 150 million times faster... http://royal.pingdom.com/2012/04/19/world-internet-population-has-doubled-in-the-last-5-years/ http://www.internetworldstats.com/stats.htm http://www.investintech.com/content/historyinternet/ http://edition.cnn.com/2013/01/25/business/fastest-internet-connection/index.html my "you get the drift?" rift about airships: http://phys.org/news/2013-01-high-tech-cargo-airship-built-california.html#nwlt http://www.aeroscraft.com/#/aeroscraft/4567337667 http://www.aeroscraft.com/#/aeroscraft-family/4565621879 I've been enjoying watching high altitude airship technology evolve for years: with thin 20% power solar cell film on top, it can go and stay anywhere with zero emissions and no fuel costs -- design can reach km scale sizes per unit, which can be linked like railroad cars in a train -- mansions for the rich, luxury cruise hotels for everyone, low cost travel for many, super precision geological surveys of entire Earth, quiet safe clean... easy to foresee speeds of 400 mph at 30,000 feet, above the weather -- the largest passenger jet now is the Airbus A380, which can carry 960 people with a lift load of 650 tons, which includes a huge fuel load -- so this prospective airship could carry as many in comfort... teams are planning larger airships to stay at 12 miles and then at 24 miles, and suggesting versions that can slowly soar for a week with solar power to gently go into polar orbit... then lunar orbit, then the planets and asteroids... nonpolluting highway to space -- current huge high altitude airship projects based on solar cells may fit with an unshielded, light-weight versions of simple, safe Hyperion uranium hydride 5,000 KW fission reactor: Otis Peterson: Rich Murray 2007.12.02 http://groups.yahoo.com/group/rmforall/message/74 ...Looking for a bigger payload capacity -- check out the monstrous Aeroscraft ML866, a superyacht for the sky. http://www.gizmag.com/go/8132/ Aeroscraft ML866: superyacht for the sky officially launched Image Gallery (16 images) October 8, 2007 It’s as big as a superyacht, and not quite as fast as a supercar but it does have a range of over 3000 miles and can do it over land, sea or snow, lingering anywhere you like the view. A new category of aircraft that fits somewhere in between a blimp, airship or dirigible, the Aeroscraft ML866 project was recently presented at the National Business Aviation Association (NBAA) show in Atlanta, Georgia... Rich Murray, MA Boston University Graduate School 1967 psychology, BS MIT 1964 history and physics, 254-A Donax Avenue, Imperial Beach, CA 91932-1918 rmfor...@gmail.com 505-819-7388 cell 619-623-3468 home http://rmforall.blogspot.com apoE4 protein scaffold allows growth of human neurons in lab, Kwang-Min Kim et al, Brown U -- can test harm from formaldehyde made from methanol by ADH1 enzyme inside cells of inner walls of brain blood vessels, WC Monte paradigm: Rich Murray 2013.01.29 http://rmforall.blogspot.com/2013/01/apoe4-protein-scaffold-allows-growth-of.html Initial tests could use micro gram amounts of formaldehyde to show the typical processes of harm within neurons: confirms WC Monte paradigm: ingested methanol becomes toxic formaldehyde-induced hydroxymethyl DNA adducts in all tissues in rats, sensitive C13 test, Kun Lu, James A Swenberg, UNC Chapel Hill 2011.12.08 Toxicol Sci: Rich Murray 2013.01.11 http://rmforall.blogspot.com/2013/01/confirms-wc-monte-paradigm-ingested.html Then, if neurons can be grown along with small brain blood vessels, with ADH1 enzyme free floating within the cells of the inner layers of the vessels, the effects of formation of formaldehyde in situ from micro grams of added methanol can be studied, confirming the WC Monte paradigm, described in detail at www.WhileScienceSleeps.com and backed by a free online archive of 745 full text medical research references. http://medicalxpress.com/news/2013-01-culture-central-nervous-cells.html#nwlt Better way to culture central nervous cells found January 29, 2013 by Kevin Stacey in Medical research Enlarge A more dependable scaffold for neural cell culture: Rat central nervous system cells cultured in the apoE4 protein (right) fare better, with more axons and dendrites than cells cultured in laminin (left). Ironically, apoE4 is associated with the neural deficits of Alzheimer's disease in the body. Credit: Palmore lab/Brown University A protein associated with neuron damage in people with Alzheimer's disease is surprisingly useful in promoting neuron growth in the lab, according to a new study by engineering researchers at Brown University. The findings, in press at the journal Biomaterials, suggest a better method of growing neurons outside the body that might then be implanted to treat people with neurodegenerative diseases. The research compared the effects of two proteins that can be used as an artificial scaffold for growing neurons (nerve cells) from the central nervous system. The study found that central nervous system neurons from rats cultured in apolipoprotein E-4 (apoE4) grew better than neurons cultured in laminin, which had been considered the gold standard for growing mammalian neurons in the lab. "Most scientists assumed that laminin was the best protein for growing CNS (central nervous system)," said Kwang-Min Kim, a biomedical engineering graduate student at Brown University and lead author of the study, "but we demonstrated that apoE4 has substantially better performance for mammalian CNS neurons." Kim performed the research under the direction of Tayhas Palmore, professor of engineering and medical science and Kim's Ph.D. adviser. Also involved in the project was Janice Vicenty, an undergraduate from the University of Puerto Rico, who was working in the Palmore lab as a summer research fellow through the Leadership Alliance. The results are surprising partly because of the association of apoE4 with Alzheimer's. Apolipoproteins are responsible for distributing and depositing cholesterols and other lipids in the brain. They come in three varieties: apoE2, apoE3 and apoE4. People with the gene that produces apoE4 are at higher risk for amyloid plaques and neurofibrillary tangles, the hallmarks of Alzheimer's. But exactly how the protein itself contributes to Alzheimer's is not known. This study suggests that outside the body, where the protein can be separated from the cholesterols it normally carries, apoE4 is actually beneficial in promoting neuron growth. Growing new neurons In the body, neurons grow in what's called an extracellular matrix (ECM), a protein-rich scaffold that provides cells with nutrients and a molecular structure in which to grow. To grow neurons in the lab, scientists try to mimic the ECM present in the body. Laminin is a common protein in the body's ECM, and studies have shown that laminin aids the growth of neurons from the peripheral nervous system (nerve cells that grow outside the brain and spinal cord). It was largely assumed, Kim said, that because laminin was good for growing peripheral nerve cells, it would also be good for growing central nerve cells. That turns out not to be the case. Kim was inspired to test the effects of apoE4 by a previous study that found that a mixture of apoE4 and laminin promoted CNS cell growth better than laminin alone. "The previous work hadn't tested the effects apoE4 by itself," Kim said. "So we started working on a side-by-side comparison of apoE4 and laminin." Kim and his colleagues cultured rat hippocampal cells — a model for mammalian CNS neurons — in four different treatments: laminin, laminin and apoE4 mixed, apoE4 alone, and bare glass. They found that cells cultured in apoE4 alone performed substantially better than any other treatment. The apoE4 cells were more likely to adhere to the protein scaffold, which is necessary for proper growth. They also showed more robust growth of axons and dendrites, the wire-like appendages that enable neurons to send and receive nerve signals. Laminin doesn't seem to be of much benefit at all for culturing CNS cells, according to the study. Cells cultured on laminin alone did not perform any better than cells cultured on bare glass. That was another big surprise, Kim said, because laminin is so widely used in all kinds of neuron cultures. A second part of the research looked at the chemical pathways through which proteins may enhance neuron growth. Previous work had found two neuron receptors, the gateways through which neurons interact with the outside world, that play a role in how external proteins trigger cell growth. However, when Kim blocked these two receptors, known as integrin and HSPG, he found that apoE4 still enhanced neuron growth. That finding suggests that neurons use an as yet unknown pathway to interact with apoE4. "This discovery opens up a new target for researchers who are interested in identifying receptors that are important for spurring neural growth," Palmore said. Application to neural prosthetics Unlike other cells in the body, nerve cells tend not to regenerate after being damaged by disease or trauma. So researchers hope that they can eventually implant lab-grown cells in the body to treat trauma or neurodegenerative diseases like Alzheimer's. "People are looking at all these different proteins to see if we can make a material — a scaffold — that to a neuron, looks and feels like their natural environment," said Palmore. "The finding that apoE4 is a better protein to add to neural scaffolds is a good breakthrough because most people have been using laminin for the central nervous system models, which turns out to be less than optimal." More information: www.sciencedirect.… 961213000203 Journal reference: Biomaterials Provided by Brown University Read more at: http://medicalxpress.com/news/2013-01-culture-central-nervous-cells.html#jCp http://www.sciencedirect.com/science/article/pii/S0142961213000203 abstract and images Biomaterials. 2013 Jan 23. pii: S0142-9612(13)00020-3. doi: 10.1016/j.biomaterials.2013.01.012. [Epub ahead of print] The potential of apolipoprotein E4 to act as a substrate for primary cultures of hippocampal neurons. Kim KM, Vazquez JV, Palmore GT. School of Engineering, Brown University, Providence, RI 02912, USA; Center for Biomedical Engineering, Brown University, Providence, RI 02912, USA. Abstract The E4 isoform of apolipoprotein (apoE4) is known to be a major risk factor for Alzheimer's Disease (AD). Previous in vitro studies have shown apoE4 to have a negative effect on neuronal outgrowth when incubated with lipids. The effect of apoE4 itself on the development of neurons from the central nervous system (CNS), however, has not been well characterized. Consequently, apoE4 alone has not been pursued as a substrate for neuronal cultures. In this study, the effect of surface-bound apoE4 on developmental features of rat hippocampal neurons was examined. We show that apoE4 substrates elicit significantly enhanced values in all developmental features at day 2 of culture when compared to laminin (LN) substrates, which is the current substrate-of-choice for neuronal cultures. Interestingly, the adhesion of hippocampal neurons was found to be significantly lower on LN substrates than on glass substrates, but the axon lengths on both substrates were similar. In addition, this study demonstrates that the adhesion- and growth-enhancing effects of apoE4 substrates are not mediated by heparan sulfate proteoglycans (HSPGs), proteins that have been indicated to function as receptors or co-receptors for apoE4. In the absence of lipids, apoE4 appears to use an unknown pathway for up-regulating neuronal adhesion and neurite outgrowth. Our results indicate that apoE4 is better than LN as a substrate for primary cultures of CNS neurons and should be considered in the design of tissue engineered CNS. Copyright © 2013. Published by Elsevier Ltd. PMID: 23352042 Kwang-Min Kim a, b, <kwang-min_...@brown.edu>, Janice Vicenty Vazquez d, G. Tayhas R. Palmore a, b, c, , <tayhas_palm...@brown.edu>, a School of Engineering, Brown University, Providence, RI 02912, USA b Center for Biomedical Engineering, Brown University, Providence, RI 02912, USA c Department of Chemistry, Brown University, Providence, RI 02912, USA d Department of Chemical Engineering, University of Puerto Rico, Mayagüez, PR 00681, USA Corresponding author at: School of Engineering, Brown University, 182 Hope Street, Box D, Providence, RI 02912, USA Tel.: +1 401 863 2856 fax: +1 401 863 1309 . Rich Murray, MA Boston University Graduate School 1967 psychology, BS MIT 1964 history and physics, 254-A Donax Avenue, Imperial Beach, CA 91932-1918 rmfor...@gmail.com 505-819-7388 cell 619-623-3468 home http://rmforall.blogspot.com
