Solved. The problem was PyMySQL for python 2.7 (used by my web2py).

With pip install PyMySQL it install for Python 3.8.

I installed PyMySQL for python 2.7 with:
wget https://bootstrap.pypa.io/pip/2.7/get-pip.py 
python2 get-pip.py 
python2 -m pip install PyMySQL


Il giorno venerdì 25 marzo 2022 alle 23:13:20 UTC+1 Fabio Ceccarani ha 
scritto:

> Hi, 
> I updated Linux Mint to last versione and MySQL was updated from version 
> 5.7 to version 8.0.
> Now my application return this error:
> <class 'gluon.contrib.pymysql.err.InternalError'> (1043, u'Bad handshake')
>
> I tried several possible solutions, install and reinstall pymysql, etc, 
> etc... but nothing!
>
> I tried to install mysq 5.7 but now it's hard to go back!
>
> Someone encountered the same problem??!
>
> Thanks!
> Fabio
>

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