You will need to set up a static route entry to allow all outside traffic via 
an outside (global address - legitimate) address seen by the internet to the 
inside (NAT/PAT) address in addition to your smtp permit entry. Use the 
following example in PIX  configuration mode:
static (inside,outside) 65.88.210.244 172.16.12.27 netmask 255.255.255.255 0 
0
access-list 100 permit tcp any host 65.88.210.244 eq smtp

The IP address of 172.16.12.27 would be the inside address of your mail 
server and 65.88.210.244 would be the outside or NAT'd?PAT'd IP address of 
your mail server. The netmask information is required and the example above 
shows that this server is statically addressed and routed to your mail 
server.

Don't forget to enable your access list with the access-group command!
access-group 100 in interface outside

As recommended by someone else - you should develop a webmail server with SSL 
to be more confident with your security. Once you do this, you will also have 
to add a static route entry for the webmail server as well as an access list 
entry.

Or hire me since I just got laid-off!  :)
Good Luck
V/r
Rob Clark

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