Cost is probably going to be a factor. Mcafee has a product in addition to VirusScan that you can use to manage all hosts from a single console. It's E-Policy Orchestrator. I don't believe Sophos has anything except reporting.
sophos has since a *really* long time
savadmin & enterprisemanager
but you can download the ides via script to the server, *you_say* how often, and tell the clients while installation check every *time_you_will* your local server for new ides and do this as user-sweepupd.
http://www.sophos.com/products/
Not sure about Trend Micro. If you want to be adventurous, you can manage it all through scripting.
-- shrek-m
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