Hello,
The new very updated to be taken on warning are published on AIDS MEDs
Combining Invirase and Garlic Capsules Not Recommended
The combinations arae oftens taken by and herbalism or TCM who knows
garlic as antiviral agent for HIV.
Please read bellows:
June 11, 2008
Garlic supplements may lower blood concentrations of the protease
inhibitor Invirase (saquinavir) and should not be used at the same time
if an Invirase-boosting dose of Norvir (ritonavir) is not also being
taken. The new recommendation, announced by the U.S. Food and Drug
Administration, comes as part of a larger revision to the package insert
for Invirase.
Scientists have known about the potential drug interaction since 2001,
when a study by the National Institutes of Health (NIH) found that
garlic capsules reduced blood levels of saquinavir, in the absence of
Norvir, by almost 50 percent. Garlic can cause the body to produce more
of an enzyme called CYP 3A4, which is needed to break down saquinavir
and many other ARV drugs, thus causing those drugs to be eliminated from
the body more rapidly than is desired.
The latest revision of Invirase’s package insert now says that the
combination of unboosted Invirase and garlic capsules is “not
recommended.” Provided that low-dose Norvir booster is used, which is
currently recommended for anyone taking Invirase, supplementing with
garlic capsules is permitted.
Further revisions to the package insert include drug interaction
warnings and dosing recommendations for Invirase and several other
drugs, including methadone, Prilosec (omeprazole), the heart drug
digoxin and the protease inhibitor Aptivus (tipranivir).
Although garlic can potentially affect blood levels of other ARV drugs,
the FDA is issuing a warning only for uboosted Invirase at this time.
The recommendation applies only to the use of garlic supplements, as
these contain much higher concentrations of the herb than the raw product.
--
"Absolutely Drug less Health Care solution Organization"
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