Dear Colleagues,

A recent article published in the February 20, 2018 edition of Annals of 
Internal Medicine that purported to review the evidence underpinning the SEP-1 
measure has been corrected by the editors of the journal due to 
misrepresentations of fact.  While the article contained several false 
assertions, perhaps the single correction that exposes the pervasive nature of 
the inaccuracies was that the editors believed it necessary to change even the 
title of the publication.

The letter to the editor prompting the correction can be found here: 
http://annals.org/aim/fullarticle/2675610/evidence-underpinning-centers-medicare-amp-medicaid-services-severe-sepsis-septic

Despite these required corrections, the authors maintain their assertion that 
have reviewed the evidence supporting SEP-1 properly in reaching their 
conclusions.  While this systematic review adjudicated the evidence based upon 
the assessments of the authors, the limitations of a single-center 
self-commissioned review without access to all CMS program data are 
self-revealing.  We note that the National Quality Forum which reviewed the 
measure in 2017 impanels a committee of national experts from a variety of 
institutions (vetted for conflicts of interest), is transparent, and includes 
an opportunity for an open notice and comment period to consider external 
expert and public feedback. In 2017, the NQF committee concluded that the level 
of evidence supporting the composite measure was "moderate." The measure was 
ultimately reendorsed with 4, 9, and 0 members evaluating the evidence as high, 
moderate, and low, respectively. The NQF review was multi-institutional, 
evaluated the evidence using the most up-to-date standards, and had access to 
program data that the Annals authors did not review.

Sean R. Townsend, M.D.
Vice President of Quality & Safety
California Pacific Medical Center
2351 Clay Street, 7th Floor
San Francisco, CA 94115
email [email protected]<mailto:[email protected]>
office (415) 600-5770
fax (415) 600-1541

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