The following are quotes from a medline search on "photolyase" It appears that there is an emerging body of evidence that correlates oxygen therapy, rife (light) therapy and minerals (silver/photosensitivity).
if anyone wants i would be happy to forward a copy the abstracts i got > from the search or you could do the search yourself. I wonder if there is relation between the FDA's stance on silver and tryptophan and the apparent correlation between PHOTOLYASE, silver and tryptophan. (repair of genetic damage by light) Whats the relationship of the light (inner/outer) to phi (geometry) ? How does deuterium fit in? I couldn't help noticing in the abstracts. "blue light" tryptophan sulfonyl In Light Wesley Eldon Price [email protected] "DNA photolyase is a light-dependent DNA repair enzyme. It binds to cyclobutane pyrimidine dimers <PyrPyr> in DNA and upon excitation with a blue light photon splits the cyclobutane ring and restores the pyrimidines to native forms. The enzyme is specific for pyrimidine dimers, and it is not known to catalyze any other reaction either in ground or in excited state. However, when photolyase binds to <PyrPyr> but cannot catalyze repair because of lack of photoreactivating light, it still aids DNA repair by stimulating the nucleotide excision repair system." "Photolyases reverse the harmful effects of UV light on cells by converting pyrimidine dimers (Pyr[]Pyr) into two pyrimidine monomers by utilizing near-UV and visible light." "of cultured goldfish cells, is known to be enhanced by fluorescent light. We have now found that H2O2 is another strong inducer of cyclobutane pyrimidine dimer photolyase. Northern blot analysis suggested that regulation by H2O2 occurs at the transcriptional level and the time course of induction of photolyase by H2O2 was similar to that by fluorescent light. Treatment with fluorescent light in the presence of riboflavin, which is known as an endogenous photosensitizer, also enhanced the induction of photolyase. These results suggest the involvement of oxygen stress in the induction of photolyase by fluorescent light" "Photoreactivating enzyme (DNA photolyase) repairs DNA by utilizing the energy of visible light to break the cyclobutane ring of the dimer. " "Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner." "the (6-4) photoproduct photolyase converts the photoproduct to unmodified bases probably through an oxetane intermediate. " "human white blood cells contain photolyase that can photorepair pyrimidine dimers in defined supercoiled and linear DNAs and in a 287-bp oligonucleotide and that human photolyase is active on genomic DNA in intact human cells." "Photoreactivating enzyme, DNA photolyase, reduces lethal, mutagenic and carcinogenic effects of ultraviolet light (UV) by catalyzing near UV or visible light-dependent repair of cyclobutane pyrimidine dimers (CPDs) in DNA." "The data are consistent with the proposal that electron transfer initiates DNA repair in the photolyase reaction." "Dimensions and polarity of the hole match those of a Pyr <> Pyr dinucleotide, suggesting that the Pyr <> Pyr "flips out" of the helix to fit into this hole, and that electron transfer between the flavin and the Pyr <> Pyr occurs over van der Waals contact distance." "We propose this gene encodes a candidate Chlamydomonas blue light photoreceptor." "(Methylsulfonyl)FAD reacts with a single cysteine residue (Cys293) in the flavin domain of Escherichia coli DNA photolyase" "Role of tryptophans in substrate binding and catalysis by DNA photolyase."
