On Mon, 20 Oct 2008 12:29:47 +0100
Dee <d...@deetroy.org> wrote:

> I had a thought about this.  Didn't the latter come about because it 
> became somewhat 'undesirable' to test things actually on people?  In
> the early days when things like bella donna and arsenic were used,
> they must have tested the doses on people in order to decide what
> were the beneficial amounts to take, mustn't they?  I presume the
> poor were used as they would have been expendable in those dark
> times, as they were used for a lot of experimentation. 
> By this thinking, I would have thought that anecdotal evidence and 
> experience, should be superior to laboratory testing because the
> results are irrefutable.  There are too many variables in laboratory
> tests to be accurate when it comes to people actually *using* stuff.
> Take Vioxx for example, and Thalidomide.  *They* were presumably
> laboratory tested, but look at the disasters caused when given to
> people!   Just a  notion.  dee
> 
> 

I believe you are addressing the question "can a laboratory model make
accurate predictions about the effect of a given substance on a human
body?" (to which the answer is, of course, "once in a blue moon":)).
That is a very different question from "what is the exact chemical
composition of a given substance and how does it behave over time?". 

In fact, your question is surely more relevant to most of us.
Unfortunately, clinical double-blind studies are expensive to conduct,
and most of them are financed by companies who make their money from
patent medicines, or researchers working with grant money, so they have
a powerful incentive to skew the results of these studies (it's either
"re-qualify for the grant money" or "get this product approved"), and
also often to avoid head-to-head comparisons of (for example) CS and
vancomycin. But the corruption rampant in the pharmaceutical industry
should not be read as an indictment of scientific method. The problem
is Big Pharma doing "science theater" rather than real science. For
instance the clinical studies *did* catch the big problems with Vioxx,
and the manufacturer simply covered it up. This sort of thing happens
all the time in the pharmaceutical industry. So perhaps it is not
unreasonable to consider anecdotal evidence more trustworthy than
information from the FDA or Upjohn, but it's still not as reliable as
the scientific method. That "correlation does not imply causation" has
been more than adequately proven. OTOH, "where there is smoke there is
fire" does work a lot of times, too. :)

Just my $.02...

indi








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