Wow! Very nice indeed Steve; Thank you! And just as a confusion factor, what do you suppose they (you know, "them") mean by: "elemental silver, even its so-called "nano-crystalline" state"? Possibly Tetra-silver (so-called?), or possibly finely divided - as in precipitated metallic Ag? - didn't the Russians experiment with that?
"As confirmed experimentally, only samples containing silver compounds can deliberate silver ions in the tested media and exhibit antimicrobial activity both in vitro and in vivo." Again; Huh?? I'd think there was enough electrochemical activity in a significant wound to provoke some ionic transport; wasn't that part of what Dr. R. O. Becker investigated, and what he developed in his work with Argentum Medical; i.e. the Silverlon bandages? I wish he'd been given the credit so richly due him for his work with silver as well as with electromedicine, deep wound and bone multiple infection control, tissue regeneration, and recalcitrant (umm,) bone fracture healing. Oh well, at least they're beginning to catch up to him. On Mon, 2009-12-07 at 18:18 -0600, Norton, Steve wrote: > Here is some information that I thought the group might be interested > in. > > http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=ECSTF8000011000021000001000001&idtype=cvips&gifs=yes > > Treatment of Various Surfaces with Silver and its Compounds for > Topical Wound Dressings, Catheter and Other Biomedical Applications > > “The applications of surfaces treated with silver and its compounds > include devices used as topical wound dressings, urinary catheters, > endotracheal tubes, cardiac valves etc. Treatment of surfaces e.g. > textile, polymers or metals with silver or its compounds is carried > out to achieve the antimicrobial action of silver ions. Several > approaches of surface treatment of medical devices for the > antimicrobial purposes, such as electrodeposition, electroless > deposition, physical vapor deposition, Picture (Device Independent > Bitmap)- radiation, etc. have been used in practice. It is clear that > only silver ions are responsible for the antimicrobial activity. As > confirmed experimentally, only samples containing silver compounds can > deliberate silver ions in the tested media and exhibit antimicrobial > activity both in vitro and in vivo. There is no evidence that > elemental silver, even its so-called "nano-crystalline" state, > exhibits an antimicrobial activity. Consequently, the devices coated > with "nano-crystalline" silver should carefully be taken into > consideration before the application.” > > Full article in google books: > > http://books.google.com/books?id=mWFylRiXV8cC&pg=PT9&lpg=PT9&dq=% > 22Treatment+of+various+surfaces+with+silver+and+its+compounds+for > +topical+wound+dressings% > 22&source=bl&ots=ixGCz2qti9&sig=of-Mkcn3VyMVbo0syg6hZMiY788&hl=en&ei=-pMdS7rvN87anAfX2dzeAw&sa=X&oi=book_result&ct=result&resnum=2&ved=0CBIQ6AEwAQ#v=onepage&q=%22Treatment%20of%20various%20surfaces%20with%20silver%20and%20its%20compounds%20for%20topical%20wound%20dressings%22&f=false > > “Based on the observation that metallic silver may exhibit some > antimicrobial activity, when sufficiently long in contact with > interstitial fluids, and considering the fact that only silver ions, > and not silver metal, are responsible for the antimicrobial activity. > One can conclude that electrochemical or corrosion phenomena plays a > significant role in the antimicrobial activity of pure silver.” > > > Some more food for thought. > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127333/ > > Chemiosmotic Mechanism of Antimicrobial Activity of Ag+ in Vibrio > cholerae > > “Although the antimicrobial effects of silver salts were noticed long > ago, the molecular mechanism of the bactericidal action of Ag+ in low > concentrations has not been elucidated. Here, we show that low > concentrations of Ag+ induce a massive proton leakage through the > Vibrio cholerae membrane, which results in complete deenergization > and, with a high degree of probability, cell death.” > > > - Steve N > -- The Silver List is a moderated forum for discussing Colloidal Silver. Instructions for unsubscribing are posted at: http://silverlist.org To post, address your message to: silver-list@eskimo.com Address Off-Topic messages to: silver-off-topic-l...@eskimo.com The Silver List and Off Topic List archives are currently down... List maintainer: Mike Devour <mdev...@eskimo.com>
